Help For Irritable Bowel Syndrome (IBS) - Education, Support, & Self Help for Irritable Bowel Syndrome
Heather & Company View Cart
Shop for IBSIBS Message BoardsIBS News & ReviewsStore Finder
Home
IBS Diet & Recipes
IBS Books
IBS Supplements
Yoga for IBS
Hypnosis for IBS
Tummy Teas
Get The IBS Diet Cheat Sheet
Get Trigger Foods, Safe Foods, Ten Commandments of Eating for IBS, More!

Enter First Name:

Enter Email:

We value your privacy


All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7677
Loc: Seattle, WA
Colonic bile acid exposure influenced IBS symptoms
      05/22/14 04:50 PM

Colonic bile acid exposure influenced IBS symptoms, therapy
Bajor A. Gut. 2014;doi:10.1136/gutjnl-2013-305965.

ay 15, 2014

Patients with irritable bowel syndrome, primarily those who were nonconstipated, had elevated levels of colonic bile acid that was indicative of abnormal 75Se-labeled homocholic acid-taurine retention and high 7 alpha-hydroxy-4-cholesten-3-one serum levels in a recent study.
Swedish researchers enrolled 141 patients (mean age, 35.3 years; 72.3% women) with irritable bowel syndrome (IBS), who were subclassified as IBS-diarrhea predominant (IBS-D; n=65), IBS-constipation predominant (IBS-C; n=26) and alternating IBS (IBS-A; n=50). They measured patients for 75Se-labeled homocholic acid-taurine (75SeHCAT) retention, serum levels of 7 alpha-hydroxy-4-cholesten-3-one (C4) and fibroblast growth factor (FGF19).

The IBS cohort had lower 75SeHCAT retention values (28 ± 19% vs. 39 ± 18%; P=.005) at 7 days than 29 healthy controls without GI symptoms, and IBS patients displayed greater levels of C4c than controls (n=435) when adjusted for cholesterol (P<.001). FGF19 was considered similar.

Eighteen percent of IBS patients demonstrated abnormal 75SeHCAT retention (<10%), and 30 of 133 evaluable patients had high C4c values. Those with abnormal 75SeHCAT retention had more frequent stools (2.9 vs. 2.1 stools/daily; P=.01), greater BMI (26 vs. 23.1 kg/m2; P=.002), accelerated colonic transmit time (0.9 vs. 1.9 days; P=.007), rectal hyposensitivity (48.7 vs. 38.9 mm Hg; P=.008) and C4c values (11.5 vs. 3.7 mg/mol; P=.02), and lower FGF19 levels (99.2 vs. 149.7 pg/mL; P=.002) than IBS patients with 75SeHCAT retention greater than 10%.

IBS patients (n=27) treated with colestipol for up to 8 weeks showed improved IBS Severity Severity Scoring System grades (P<.01), including 15 patients who met treatment response criteria of at least 50% adequate relief of weeks 5 through 8.

“Our findings … strengthen the involvement of increased bile acid exposure in the colon as a partial mechanism for symptom generation in patients with especially nonconstipated IBS, that is, IBS-D and IBS-A,” the researchers concluded. “The positive symptomatic response to open label treatment with bile acid binders in patients with IBS with low 75SeHCAT values supports a role of bile acids in IBS symptomatology, but placebo-controlled studies are warranted.”

http://www.healio.com/gastroenterology/irritable-bowel-syndrome/news/online/%7B46b70fe3-d645-48bf-b29b-899c7f150fab%7D/colonic-bile-acid-exposure-influenced-ibs-symptoms-therapy

--------------------
Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Post Extras Print Post   Remind Me!     Notify Moderator

Entire thread
Subject Posted by Posted on
* General IBS / Bowel Dysfunction HeatherAdministrator 07/14/03 01:56 PM
. * April is IBS Awareness Month: 10 recent advances in research, diagnostics HeatherAdministrator   04/16/18 02:05 PM
. * Bacteria can trigger stomach cancer HeatherAdministrator   08/25/17 04:11 PM
. * Fecal microbiota transplantation improved symptoms and quality of life in patients with IBS HeatherAdministrator   05/09/17 01:28 PM
. * Autism symptoms improve after fecal transplant, small study finds HeatherAdministrator   01/26/17 02:54 PM
. * Microbiota and arthritis: correlations or cause? HeatherAdministrator   02/19/16 01:09 PM
. * Takeda, Enterome to collaborate on microbiome-based drugs for IBD, IBS, other GI disorders HeatherAdministrator   01/11/16 03:21 PM
. * Risk factors for IBS in military include stress, infectious gastroenteritis HeatherAdministrator   01/11/16 03:19 PM
. * Risk Factors ID'd for Fecal Transplant Failure