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All Boards >> Irritable Bowel Syndrome Research Library


Reged: 12/09/02
Posts: 7677
Loc: Seattle, WA
Role of Antibiotics vs Conventional Pharmacotherapy in Treating Symptoms of Irritable Bowel Syndrome
      01/03/08 04:45 PM

Review Article: The Role of Antibiotics vs Conventional Pharmacotherapy in Treating Symptoms of Irritable Bowel Syndrome

C. L. Frissora; B. D. Cash

Conclusion: Antibiotics are an emerging therapeutic option for IBS, and many questions surrounding the exact role of enteric bacteria in the diagnosis and management of IBS remain unanswered. Results to date suggest that appropriately targeted antibiotic therapy may offer important benefits as an alternative to, or in addition to, symptom-directed pharmacotherapies in the treatment of IBS. Clear demonstration of superiority of one treatment approach over another will require a suitably designed, randomized, placebo-controlled trial. Given the breadth of the IBS symptom spectrum and current limitations in symptom-directed therapies related to adverse effects and blinding, it is unlikely that such a trial will be conducted. More likely, continued reports of efficacy with directed antibiotic therapy in patients with symptoms consistent with IBS or other functional GI disorders will lead to the complementary use of these medications in a stepwise or combined fashion. The potential benefit of antibiotics in diminishing the need for chronic daily pharmacotherapy or reducing the frequency of repeated courses of therapy in IBS warrants additional exploration.

Aliment Pharmacol Ther. 2007;25(11):1271-1281. ©2007 Blackwell Publishing

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