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Heather

Reged: 12/09/02

Posts: 7077

Loc: Seattle, WA

Role of Antibiotics vs Conventional Pharmacotherapy in Treating Symptoms of Irritable Bowel Syndrome
01/03/08 04:45 PM

Review Article: The Role of Antibiotics vs Conventional Pharmacotherapy in Treating Symptoms of Irritable Bowel Syndrome

C. L. Frissora; B. D. Cash

Conclusion: Antibiotics are an emerging therapeutic option for IBS, and many questions surrounding the exact role of enteric bacteria in the diagnosis and management of IBS remain unanswered. Results to date suggest that appropriately targeted antibiotic therapy may offer important benefits as an alternative to, or in addition to, symptom-directed pharmacotherapies in the treatment of IBS. Clear demonstration of superiority of one treatment approach over another will require a suitably designed, randomized, placebo-controlled trial. Given the breadth of the IBS symptom spectrum and current limitations in symptom-directed therapies related to adverse effects and blinding, it is unlikely that such a trial will be conducted. More likely, continued reports of efficacy with directed antibiotic therapy in patients with symptoms consistent with IBS or other functional GI disorders will lead to the complementary use of these medications in a stepwise or combined fashion. The potential benefit of antibiotics in diminishing the need for chronic daily pharmacotherapy or reducing the frequency of repeated courses of therapy in IBS warrants additional exploration.

Aliment Pharmacol Ther. 2007;25(11):1271-1281. ©2007 Blackwell Publishing

http://www.medscape.com/viewarticle/557851_4

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Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Subject	Posted by	Posted on
Pharmaceutical	Heather	07/14/03 01:50 PM
On Anti-Depressants? Some Raise Risk of C. Diff Infection	Heather	05/13/13 05:51 PM
Heartburn drugs, NSAID painkillers use linked to IBS symptoms	Heather	03/18/13 01:24 PM
FDA approves Linzess to treat certain cases of irritable bowel syndrome and constipation	Heather	08/31/12 11:25 AM
3-month FDA delay for potential IBS drug linaclotide	Heather	04/23/12 01:45 PM
Latest FDA watch list includes GI drugs	Heather	04/23/12 01:42 PM
Antibiotics that reduce gut bacteria linked to obesity	Heather	05/06/11 12:25 PM
Rifaximin: a unique gastrointestinal-selective antibiotic for enteric diseases	Heather	02/10/11 10:23 AM
Antacids increase risk of pneumonia	Heather	01/14/11 04:35 PM
Editorial - Antibiotic Rifaximin (Xifaxan) Therapy for the Irritable Bowel Syndrome	Heather	01/07/11 03:01 PM
Antiobiotic Rifaximin (Xifaxan) for Patients with Irritable Bowel Syndrome without Constipation	Heather	01/07/11 02:59 PM
Proton Pump Inhibitor Drugs Tied to 80% Increase in Clostridium difficile Risk	Heather	11/10/10 11:29 AM
Phase 3 clinical trials of linaclotide for IBS constipation	Heather	10/13/10 02:44 PM
An over-the-counter drug for constipation offers superior symptom relief compared with a commonly used prescription agent	Heather	07/16/10 03:17 PM
Benefit/risk ratio of Renzapride not sufficient to warrant further study in IBS-C	Heather	04/07/10 01:32 PM
Adverse effects of drugs on small intestine and colon	Heather	03/16/10 11:23 AM
Children's Belly Aches Don't Disappear With Antidepressant	Heather	03/11/10 01:14 PM
Survey: Marijuana Use In Patients With IBS	Heather	01/12/10 03:17 PM
FDA Approves Amitiza for IBS-C	Heather	05/23/08 10:59 AM
Zelnorm no longer available except for emergency use	Heather	04/11/08 12:05 PM
Clinical trial: phase 2 trial of lubiprostone for irritable bowel syndrome with constipation.	Heather	02/15/08 11:20 AM
Role of Antibiotics vs Conventional Pharmacotherapy in Treating Symptoms of Irritable Bowel Syndrome	Heather	01/03/08 04:45 PM
FDA permits the restricted use of Zelnorm	Heather	08/09/07 11:41 AM
Antidepressant Therapy (Imipramine and Citalopram) for Irritable Bowel Syndrome	Heather	06/20/07 01:56 PM
Neuromuscular Dysfunction and IBS: Clinical Implications for Drug Use	Heather	02/04/07 04:30 PM
Enteric Bacteria and IBS	Heather	11/26/06 02:51 PM
Rifaximin vs Placebo in Reducing Symptoms in Adults With IBS	Heather	11/26/06 02:39 PM
Antibiotic Rifaximin Appears Safe and Effective for Irritable Bowel Syndrome	Heather	10/26/06 10:29 AM
Citalopram (Celexa) Improves Symptoms of Irritable Bowel Syndrome	Heather	10/14/06 12:57 PM
Marijuana eases chronic pain	Heather	07/17/06 11:49 AM
Doctors group launches war on drug ads	Heather	07/17/06 11:17 AM
New IBS drug in development in Japan	Heather	07/05/06 05:13 PM
Marijuana and the gastrointestinal tract	Heather	06/12/06 03:38 PM
Zelnorm Rejected Again in Europe	Heather	04/02/06 03:25 PM
Antidepressants for IBS	Heather	03/16/06 12:31 PM
Takeda Laxative Wins U.S. Approval for Adults	Heather	02/18/06 01:36 PM
Cilansetron: ; Solvay Pharmaceuticals suspends registration activites in the U.S.,	Heather	01/18/06 04:15 PM
Hearburn Drugs Cause Diarrhea	Heather	01/08/06 05:10 PM
Zelnorm fails to win EU panel backing	Heather	12/21/05 11:25 AM
Non-steroidal anti-inflammatory drugs and gastrointestinal damage	Heather	12/08/05 12:51 PM
Octreotide May Be Effective in Treatment of Nonconstipated IBS	Heather	12/08/05 12:31 PM
Lack of Lasting Effectiveness of Miralax Laxative Treatment of Constipation.	Heather	08/07/05 04:18 PM
Acute Hepatitis Associated With Lotronex	Heather	07/24/05 02:37 PM
FDA revisions to safety labeling for Lotronex (alosetron )	Heather	05/22/05 06:46 PM
Clinical pharmacology of new motility promoting agents	Heather	05/22/05 06:33 PM
Rationale for Using Serotonergic Agents to Treat Irritable Bowel Syndrome	Heather	05/08/05 06:21 PM
Zelnorm Associated With Rare Cases of Severe Diarrhea, Ischemic Colitis	Heather	04/24/05 03:48 PM
Clinical Response to Tricyclic Antidepressants in Functional Bowel Disorders not Related to Dosage	Heather	03/28/05 01:32 PM
Efficacy and Safety of Alosetron in Men with Diarrhea-Predominant IBS	Heather	02/19/05 05:56 PM
Irritable Bowel Syndrome Medications Side Effects Survey	Heather	11/09/04 02:04 PM
On the Relationship Between Colon Ischemia, Irritable Bowel Syndrome, and Serotonergic Therapy of Irritable Bowel Syndrome	Heather	10/24/04 07:10 PM
New Risk Information on Zelnorm for IBS for Women	Heather	07/11/04 02:18 PM
The Relationship among Previous Antimicrobial Use and H. Pylori Infections	Heather	06/27/04 01:33 PM
Therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome	Heather	06/04/04 03:54 PM
Pharmaceutical companies funding a number of studies into IBS in the UK	Heather	05/25/04 12:00 PM
Irritable bowel syndrome helped by Paroxetine, a drug for depression	Heather	05/10/04 02:15 PM
Fears cause low sales of Lotronex	Heather	05/10/04 01:46 PM
Zelnorm Warning Issued by FDA	Heather	05/10/04 01:01 PM
Renzapride Improves Symptoms in Constipation-Predominant Irritable Bowel Syndrome	Heather	12/01/03 06:14 PM
Clinical Trial Guidelines for Pharmacological Treatment of IBS - Pharmacological Options	Heather	12/01/03 05:55 PM
SOLVAY presses ahead with cilansetron, a new IBS drug	Heather	11/18/03 03:43 PM
Measuring Treatment Effects in IBS Trials	Heather	10/20/03 03:30 PM
FDA Orders Novartis To Pull Zelnorm Ads	Heather	10/07/03 11:25 PM
Step-down dosage of PPI drugs for hearburn	Heather	09/30/03 01:26 PM
Evaluation of drug treatment in irritable bowel syndrome	Heather	09/30/03 12:52 PM
Pain Relievers and Intestinal Disorders	Heather	09/16/03 04:20 PM
Hypersensitivity and hyperreactivity in IBS: opportunity for drug discovery	Heather	07/18/03 12:39 PM
Antidepressants in the Treatment of IBS and Other Functional GI Disorders	Heather	07/18/03 12:20 PM
Use of Antidepressants in the Treatment of IBS?	Heather	07/14/03 03:58 PM
Combined use of SSRIs and NSAIDs increases the risk of GI adverse effects	Heather	07/14/03 03:15 PM

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