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All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7677
Loc: Seattle, WA
Dietary means of diagnosing IBS
      02/01/06 12:10 PM

Gut. 2006 Jan 24; [Epub ahead of print] Related Articles, Links


Meal-induced recto-sigmoid tone modification: a low-caloric meal accurately separates functional and organic gastrointestinal disease patients.

Di Stefano M, Miceli E, Missanelli A, Mazzocchi S, Corazza G.

I Department of Medicine, University of Pavia, IRCCS S.Matteo Hospital, Italy.

BACKGROUND AND AIMS: Diagnosis of irritable bowel syndrome is based on arbitrary criteria due to the lack of an accurate diagnostic test. The aim of this study was to evaluate whether recto-sigmoid tone modification after a meal represents an accurate diagnostic approach. METHODS: In a secondary care setting, 32 constipation-predominant and 24 diarrhoea-predominant IBS patients, 10 functional diarrhoea and 10 functional constipation patients, 29 organic gastrointestinal disease patients and 10 healthy volunteers underwent a rectal barostat test in order to measure fasting and post- prandial recto-sigmoid tone. Recto-sigmoid response was assessed following three meals containing different amounts of calories, 200 Kcal, 400 Kcal and 1000 Kcal. RESULTS: After 200 Kcal, healthy volunteers and patients with organic diseases showed a reduction of recto-sigmoid volume of at least 28% of fasting volume, indicating a meal-induced increase of muscle tone. On the contrary, patients with diarrhoea-predominant IBS showed a dilation of the recto-sigmoid colon, indicative of reduced tone and patients with constipation-predominant IBS showed a mild volume reduction or no modification. Functional diarrhoea and constipation patients showed recto-sigmoid tone modification resembling that of the corresponding IBS subtype. A 400 Kcal meal normalized recto-sigmoid tone in more than half the constipation- predominant IBS patients but none of the diarrhoea- predominant IBS patients. On the contrary, a 1000 Kcal meal normalized tone response in all IBS patients. Sensitivity of the test was 100%, specificity 93%, positive predictive value 96% and negative predictive value 100%. CONCLUSION: A post-prandial reduction of recto- sigmoid tone of at least 28% of fasting value after a low- caloric meal accurately separates organic and functional gastrointestinal disease patients. This parameter may, therefore, be used in the positive diagnosis of IBS.

PMID: 16434428

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Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Subject Posted by Posted on
* Diet HeatherAdministrator 07/14/03 01:58 PM
. * Diet, lifestyle outweigh genetic impact on gut microbiome HeatherAdministrator   03/19/18 02:39 PM
. * Fecal Profiling May Predict Dietary Response in IBS to FODMAPS Diet HeatherAdministrator   03/15/18 11:51 AM
. * Can a Western diet permanently alter the immune system? HeatherAdministrator   01/19/18 01:17 PM
. * High-fat diet leads to same intestinal inflammation as a virus HeatherAdministrator   06/23/17 04:25 PM
. * Gluten-free diet could increase cardiovascular risk in people without celiac disease HeatherAdministrator   05/09/17 01:35 PM
. * Gut microbiome profiles predict response to low FODMAP diet in IBS HeatherAdministrator   11/02/16 02:45 PM
. * Fructose malabsorption, symptom severity, IBS subtype predict response to low FODMAP diet HeatherAdministrator   06/27/16 02:44 PM
. * Fiber-Rich Diet May Boost Lung Function HeatherAdministrator   01/27/16 02:52 PM
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