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Heather
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Reged: 12/09/02
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Posts: 7080
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Loc: Seattle, WA
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Colonoscopic Surveillance in Inflammatory Bowel Disease
10/11/05 01:33 PM
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From Current Opinion in Gastroenterology
Colonoscopic Surveillance in Inflammatory Bowel Disease
Thomas A Ullman, Mount Sinai School of Medicine, New York, New York
Curr Opin Gastroenterol. 2005;21(5):585-588. ©2005 Lippincott Williams & Wilkins
Posted 09/28/2005
Thomas A Ullman
Abstract and Introduction
Abstract
Purpose of Review: To describe recent findings in the literature aimed at decreasing systematic error in dysplasia surveillance in inflammatory bowel disease.
Recent Findings: Despite great promise, colonoscopic surveillance in inflammatory bowel disease has yet to be demonstrated to reduce colorectal cancer mortality. In part, this stems from a number of inherent systematic troubles, including low rates of observer agreement among pathologists; lack of consensus on the natural history of dysplasia, particularly low-grade dysplasia; the patchy nature of dysplasia, which leads to sampling error caused by insufficient biopsy by endoscopists; and incomplete patient follow-up. Recent publications that have focused on defining better the natural history of different levels of dysplasia and improving dysplasia identification at the time of colonoscopy may aid in overcoming the flaws of surveillance. The key recent findings include conflicting evidence on the relative danger of flat low-grade dysplasia, the safety of treating polypoid low-grade dysplasia as a benign adenoma in the absence of flat dysplasia in the rest of the colon or the surrounding mucosa, and preliminary support of chromoendoscopy to target dysplasia better during colonoscopy and to limit unnecessary nontargeted biopsies.
Summary: These and other advances stand a reasonable chance of making surveillance a more accurate tool to discriminate between patients with chronic colitis likely to progress to advanced pathology and those less likely to do so. Such advances may result in effective surveillance in which both colorectal cancer mortality and unnecessary colectomy may be limited.
http://www.medscape.com/viewarticle/510593?src=mp
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Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!
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