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All Boards >> Irritable Bowel Syndrome Research Library


Reged: 12/09/02
Posts: 7677
Loc: Seattle, WA
Physiological Mechanisms Underlying Perceptions of Nausea and Stomach Fullness
      08/07/05 04:33 PM

Sickness and Satiety: Physiological Mechanisms Underlying Perceptions of Nausea and Stomach Fullness

Max E Levine PhD

Department of Internal Medicine Section of Gastroenterology, Medical Center Boulevard, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.

Current Gastroenterology Reports 2005, 7:280-288

Published 1 August 2005


The pathophysiology of nausea and the physiological mechanisms underlying perceptions of stomach emptiness and fullness are not clearly understood, but several potentially important factors have been identified. Gastric dysrhythmias are believed to contribute to the subjective experience of nausea and may also be involved with perceptions of stomach emptiness, hunger, and even dyspepsia symptoms like bloating and early satiety.

Normal gastric neuromuscular function is more evident in the absence of nausea and is also thought to be related to feelings of satiety or comfortable stomach fullness. Autonomic and endocrine influences may also play a critical role in the pathophysiology of nausea and abnormal perceptions of stomach emptiness or fullness. Achieving a better understanding of the gastric neuromuscular and neurohormonal influences on perceptions arising from the viscera may prove invaluable in the development of novel treatments for such conditions as unexplained nausea, functional dyspepsia, and obesity.

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