Sleep and gastric function in irritable bowel syndrome: derailing the brain-gut axis
07/18/03 12:42 PM
Gut. 1997 Sep;41(3):390-3.
Sleep and gastric function in irritable bowel syndrome: derailing the brain-gut axis.
Orr WC, Crowell MD, Lin B, Harnish MJ, Chen JD.
Thomas N. Lynn Institute for Healthcare Research, INTEGRIS Baptist Medical Center of Oklahoma, Oklahoma City 73112, USA.
BACKGROUND: Recently, several studies have shown an alteration in bowel function during sleep in patients with irritable bowel syndrome (IBS), and a recent study also suggests a remarkable increase in rapid eye movement (REM) sleep. These studies have suggested that an alteration in CNS function may play an important role in the pathogenesis of IBS. AIMS: To confirm the presence of an alteration in REM sleep in patients with IBS and to assess the relation between sleep and a non-invasive measure of gastric functioning, the electrogastrogram (EGG). PATIENTS: Ten patients with IBS and 10 age and sex matched normal volunteers. METHODS: All subjects slept one night in the sleep laboratory and underwent polysomnographic monitoring to determine sleep patterns, and recording of the EGG from surface electrodes. RESULTS: The IBS group had a notable and significant increase in the percentage and duration of REM sleep (p < 0.05). The control group had a decrease in the amplitude of the dominant EGG frequency from waking to non-REM sleep (p < 0.05), and a subsequent increase in the amplitude from non-REM to REM sleep (p < 0.05). No such changes were noted in the patients with IBS. CONCLUSIONS: Results confirmed the enhancement of REM sleep in patients with IBS and suggested an intrinsic alteration in autonomic and CNS functioning in patients with IBS.
PMID: 9378397 [PubMed - indexed for MEDLINE] web page