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All Boards >> Irritable Bowel Syndrome Research Library


Reged: 12/09/02
Posts: 7677
Loc: Seattle, WA
Calcium polycarbophil compared with placebo in IBS
      07/15/03 11:10 PM

Note: Calcium polycarbophil is sold as Equalactin and Fibercon

Aliment Pharmacol Ther. 1993 Feb;7(1):87-92.

Calcium polycarbophil compared with placebo in irritable bowel syndrome.

Toskes PP, Connery KL, Ritchey TW.

Division of Gastroenterology, Hepatology and Nutrition, University of Florida College of Medicine, Gainesville 32610.

Calcium polycarbophil was compared with placebo in 23 patients with irritable bowel syndrome in a six-month, randomized double-blind crossover study. Patients received polycarbophil tablets at a dosage of 6 g/day (twelve 0.5-g tablets) or matching placebo tablets. At study end, among patients expressing a preference, 15 of 21 (71%) chose polycarbophil over placebo for relief of the symptoms of irritable bowel syndrome. Statistically significant differences favouring polycarbophil were found among the following patient subgroups: 15 (79%) of 19 with constipation: all six with alternating diarrhoea and constipation; 13 (87%) of 15 with bloating: and 11 (92%) of 12 with two or more symptoms. Polycarbophil was rated better than placebo in monthly global responses to therapy. Patient diary entries showed statistically significant improvement for ease of passage with polycarbophil. Polycarbophil was rated better than placebo for relief of nausea, pain, and bloating. The data suggest that calcium polycarbophil can benefit irritable bowel syndrome patients with constipation or alternating diarrhoea and constipation and may be particularly useful in patients with bloating as a major complaint.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 8439642 [PubMed - indexed for MEDLINE]
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