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All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7420
Loc: Seattle, WA
Alterations of sensori-motor functions of the digestive tract in the pathophysiology of IBS
09/12/04 03:44 PM

Alterations of sensori-motor functions of the digestive tract in the pathophysiology of irritable bowel syndrome

Michel Delvaux MD, PhD,

Department of Internal Medicine and Digestive Pathology, CHU de Brabois, F-54511 Vandoeuvre-les-Nancy, France

Available online 18 August 2004.




Pathophysiology of irritable bowel syndrome (IBS) is based upon multiple factors that have been organised in a comprehensive model centred around the braingut axis. The braingut axis encompasses nerve pathways linking the enteric and the central nervous systems and contains a large proportion of afferent fibres. Functionally and anatomically, visceral nerves are divided in to two categories: the parasympathetic pathways distributing to the upper gut through the vagi and to the hindgut, through the pelvic and pudendal nerves, and the sympathetic pathways, arising form the spinal cord and distributing to the midgut via the paravertebral ganglia.

Several abnormalities of gut sensori-motor function have been described in patients with IBS. Abnormal motility patterns have been described at the intestinal and colonic levels. Changes in colonic motility are mainly related to bowel disturbances linked to IBS but do not correlate with pain. More recently, visceral hypersensitivity has been recognised as a main characteristic of patients with IBS. It is defined by an exaggerated perception of luminal distension of various segments of the gut and related to peripheral changes in the processing of visceral sensations as well as modulation of perception by centrally acting factors including mood and stress.

Viscero-visceral reflexes link the two edges of the braingut axis and may account for the origin of symptoms in some pathological conditions. Recent advances in the understanding of the role of myenteric plexus allowed recognition of several neurotransmitters involved at the level of both the afferent and efferent pathways. Targeting the receptors of these neurotransmitters is a promising way for development of new treatments for IBS.

Best Practice & Research Clinical Gastroenterology
Volume 18, Issue 4 , August 2004, Pages 747-771

http://www.mdlinx.com/GILinx/thearts.cfm?artid=1041730&specid=13&ok=yes

--------------------
Heather is the Administrator of the IBS Message Boards. Shes the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Subject Posted by Posted on
* Brain-Gut HeatherAdministrator 07/14/03 01:59 PM
. * How the Gut's Second Brain Influences Mood and Well-Being HeatherAdministrator 07/15/14 03:08 PM
. * Does bacteria connect the brain and the gut? HeatherAdministrator 09/27/13 11:44 AM
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. * Brain-gut axis dysfunction in IBS HeatherAdministrator 03/16/10 11:27 AM
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. * Stress, the Brain-Gut Axis, and IBS HeatherAdministrator 07/17/07 11:34 AM
. * The Effectiveness of Hypnotherapy in the Management of Irritable Bowel Syndrome HeatherAdministrator 10/26/06 10:16 AM
. * An international study of irritable bowel syndrome: Family relationships and mind-body attributions HeatherAdministrator 06/04/06 12:28 PM
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. * Alterations of sensori-motor functions of the digestive tract in the pathophysiology of IBS HeatherAdministrator 09/12/04 03:44 PM
. * Visceral Sensitivity Index: Development and Validation of a GI Symptom-Specific Anxiety Scale HeatherAdministrator 07/24/04 01:54 PM
. * Brain activity during distention of the descending colon in humans HeatherAdministrator 07/11/04 02:07 PM
. * Irritable bowel syndrome: a model of the brain-gut interactions HeatherAdministrator 05/25/04 12:28 PM
. * The human enteric nervous system HeatherAdministrator 05/11/04 07:10 PM
. * Images Show a Snub Really Is Like Kick in the Gut HeatherAdministrator 10/20/03 03:43 PM
. * The Brain-Gut Connection HeatherAdministrator 09/01/03 11:43 AM
. * The Neurobiology of Stress and Emotions, and IBS HeatherAdministrator 07/23/03 10:35 AM
. * Gut Feelings: The Surprising Link Between Mood and Digestion HeatherAdministrator 07/23/03 10:31 AM
. * Sleep and gastric function in irritable bowel syndrome: derailing the brain-gut axis HeatherAdministrator 07/18/03 12:42 PM
. * The autonomic nervous system in functional bowel disorders. HeatherAdministrator 07/18/03 12:40 PM
. * Regional cerebral activation in irritable bowel syndrome HeatherAdministrator 07/18/03 12:36 PM
. * Intestinal reactivity to words with emotional content and brain information processing in IBS HeatherAdministrator 07/18/03 12:35 PM
. * Perceptual hyperreactivity to auditory stimuli in patients with irritable bowel syndrome. HeatherAdministrator 07/18/03 12:33 PM
. * The gut as a neurological organ. HeatherAdministrator 07/18/03 12:28 PM
. * Brain research in functional gastrointestinal disorders. HeatherAdministrator 07/18/03 12:24 PM
. * The gut has a mind of its own HeatherAdministrator 07/14/03 04:07 PM

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