I would always take it with food;Didn't cause me any problem. Suppose to be very low in causing intestinal problems.
-------------------- 7/2017: CBD oil solves some IBS spasming, expensive. Benadryl relaxes some spasming, but tiring and drying..Dizzy from presc. meds., yet still spasming.Taking less probios and more enzymes. No gluten. Weight steady. Less migraines and heartburn with double ginger bags and feverfew standardized, sometimes Imitrex. Body aches. Taking (non-frementing) methylcellulose caplets instead of having done acacia. Drinking 10C/day water constantly keeps away most trapped gas. Couldn't get disability.