Trying Prescription Drugs for Irritable Bowel Syndrome
Remember that while there are a number of different prescription medications available for IBS, their effectiveness does vary greatly from one person to another.
What particular drug (if any) will work best for you is something you'll most likely have to determine through trial and error. If the first medication you try doesn't help much, keep in mind that there are other options available.
You should work in partnership with your doctor to determine which medication best fits your needs.
Fewer CNS and anticholinergic side effects and less sedation,
orthostatic hypotension & weight gain with secondary amines;
start low and work up to target dosage. Constipation can worsen.
Vicodin (Hydrocodone), Percodan and Percocet (Oxycodone),
Demerol (Meperidine), Codeine, Morphine.
Drowsiness, dizziness, constipation, nausea. Can be
habit-forming. Possible dangerous interactions with other
prescription and over-the-counter drugs, and alcohol.
SSRIs (e.g., fluoxetine, paroxetine)
Can be used for pain
management and constipation in patients who are intolerant
Transient exacerbation of nausea; diarrhea can occur with SSRIs;
sleep disruption occurs with some agents
(e.g., buproprion, venlafaxine)
Affects multiple symptoms in diarrhea-predominant female
patients only, including pain,
urgency, and diarrhea.
May cause severe constipation and ischemic colitis. Effectiveness has not been shown in men. Lotronex was withdrawn from the U.S. market November 2000 then reintroduced under stringent prescribing guidelines.
Pain and constipation in constipation-
predominant female patients
Approved for short-term use only. Approved for women only. May cause diarrhea, bloating, pain.
Under investigation by Solvay Pharmaceutical for chronic
Under investigation by Janssen Research Foundation for chronic