All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7679
Loc: Seattle, WA
Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease
      09/13/05 01:22 PM

Risk Factors for Inflammatory Bowel Disease in the General Population

L. A. García Rodríguez; A. González-Pérez; S. Johansson; M.-A. Wallander


Background: The aetiology of inflammatory bowel disease remains largely unknown.

Aim: We performed a comprehensive assessment of potential risk factors associated with the occurrence of inflammatory bowel disease.

Methods: We identified a cohort of patients 20–84 years old between 1995 and 1997 registered in the General Practitioner Research Database in the UK. A total of 444 incident cases of IBD were ascertained and validated with the general practitioner. We performed a nested case–control analysis using all cases and a random sample of 10 000 frequency-matched controls.

Results: Incidence rates for ulcerative colitis, Crohn's disease, and indeterminate colitis were 11, 8, and 2 cases per 100 000 person-years, respectively. Among women, we found that long-term users of oral contraceptives were at increased risk of developing UC (OR: 2.35; 95% CI: 0.89–6.22) and CD (OR: 3.15; 95% CI: 1.24–7.99). Similarly, long-term users of HRT had an increased risk of CD (OR: 2.60; 95% CI: 1.04–6.49) but not UC. Current smokers experienced a reduced risk of UC along with an increased risk of CD. Prior appendectomy was associated with a decreased the risk of UC (OR: 0.37; 95% CI: 0.14–1.00).

Conclusions: Our results support the hypothesis of an increased risk of inflammatory bowel disease associated with oral contraceptives use and suggest a similar effect of hormone replacement therapy on CD. We also confirmed the effects of smoking and appendectomy on inflammatory bowel disease.


L. A. García Rodríguez*, A. González-Pérez*, S. Johansson, M.-A. Wallander

*Centro Español de Investigación Farmacoepidemiológica (CEIFE), Madrid, Spain;

AstraZeneca R&D Mölndal, Sweden;
Section of Preventive Cardiology, Göteborg University, Sweden;
Department of Public Health and Caring Science, Uppsala University, Sweden


Aliment Pharmacol Ther. 2005;22(4):309-315.

©2005 Blackwell Publishing

To read this article in full, please click here:

http://www.medscape.com/viewarticle/510581?src=mp

--------------------
Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Post Extras Print Post   Remind Me!     Notify Moderator

Entire thread
Subject Posted by Posted on
* Inflammatory Bowel Disease HeatherAdministrator 07/14/03 01:51 PM
. * Dietary fiber associated with reduced Crohn's disease flares HeatherAdministrator   01/27/16 02:58 PM
. * Probiotics not superior for maintaining ulcerative colitis remission HeatherAdministrator   12/29/15 10:12 AM
. * Fecal transplant induces remission in active ulcerative colitis HeatherAdministrator   07/16/15 04:39 PM
. * 7 recent developments in Crohn's disease HeatherAdministrator   04/02/15 03:16 PM
. * Hormonal contraception improved menstrual-related IBD symptoms HeatherAdministrator   09/15/14 12:43 PM
. * Fecal lactoferrin differentiated IBD from IBS HeatherAdministrator   07/29/14 01:50 PM
. * Vitamin D and Cancer Risk in IBD HeatherAdministrator   07/15/14 02:53 PM
. * Self-assessment scale developed for patients with IBD-fatigue HeatherAdministrator   06/17/14 10:44 AM
. * Stool test distinguishes between IBD and IBS HeatherAdministrator   04/07/14 01:40 PM
. * Breathing exercises, meditation improved inflammatory markers, quality of life in IBD patients HeatherAdministrator   10/23/13 04:20 PM
. * Inflammatory Bowel Disease: Heat Waves Linked to Flares HeatherAdministrator   08/16/13 12:58 PM
. * Dietary changes may reduce effects of IBD HeatherAdministrator   06/27/13 05:43 PM
. * Genetic Clues May Help Unravel Cause of Crohn's HeatherAdministrator   11/02/12 12:59 PM
. * Inflammatory bowel, ulcerative colitis linked to intestinal fungi HeatherAdministrator   06/15/12 01:23 PM
. * Smoking makes Crohn's disease worse HeatherAdministrator   05/09/12 01:33 PM
. * Kids With Crohn’s Disease, Colitis Often Struggle at School HeatherAdministrator   04/23/12 01:22 PM
. * As Nations Develop, So May Bowel Disease HeatherAdministrator   01/09/12 12:01 PM
. * Loneliness Triggers Inflammatory Illnesses HeatherAdministrator   02/10/11 10:05 AM
. * Infants' antibiotic use tied to IBD risk HeatherAdministrator   11/03/10 01:42 PM
. * Olive Oil May Protect Against Ulcerative Colitis HeatherAdministrator   05/05/10 10:32 AM
. * Accutane may cause ulcerative colitis HeatherAdministrator   04/09/10 01:38 PM
. * Red meat may raise odds for ulcerative colitis, but oily fish could be protective HeatherAdministrator   03/11/10 01:22 PM
. * Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified? HeatherAdministrator   01/05/10 12:03 PM
. * Novel Compound Targets Mucosal Healing in Crohn's HeatherAdministrator   05/29/06 02:19 PM
. * Viagra May Help Crohn's Disease HeatherAdministrator   03/04/06 12:50 PM
. * Carbon Monoxide Eases Ulcerative Colitis HeatherAdministrator   01/18/06 04:12 PM
. * Colonoscopic Surveillance in Inflammatory Bowel Disease HeatherAdministrator   10/11/05 01:33 PM
. * Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease HeatherAdministrator   09/13/05 01:22 PM
. * Cannabinoids Show Promise for Inflammatory Bowel Disease HeatherAdministrator   09/01/05 11:23 AM
. * Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome HeatherAdministrator   09/01/05 11:13 AM
. * The Clinical Epidemiology of Inflammatory Bowel Disease HeatherAdministrator   08/22/05 04:45 PM
. * IBD Patients May Benefit From Folic Acid Supplementation HeatherAdministrator   05/22/05 07:02 PM
. * Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis HeatherAdministrator   04/24/05 03:33 PM
. * Biotic Therapy Cuts Inflammation in Ulcerative Colitis HeatherAdministrator   02/19/05 05:59 PM
. * Calming Crohn's Disease with Fish Oil and Antioxidants HeatherAdministrator   01/07/05 04:55 PM
. * Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis HeatherAdministrator   12/20/04 01:37 PM
. * Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden? HeatherAdministrator   11/28/04 02:58 PM
. * Diet May Influence Relapse in Ulcerative Colitis HeatherAdministrator   10/24/04 07:50 PM
. * Parasite Therapy for Crohn's and Colitis? HeatherAdministrator   08/08/04 03:00 PM
. * Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases HeatherAdministrator   06/04/04 06:41 PM
. * Faulty Gene for Crohn's Disease Found HeatherAdministrator   04/13/04 03:19 PM
. * Data links Crohn's disease and antibiotics HeatherAdministrator   02/24/04 02:07 PM
. * Elan Reports Successful Results of Antegren Trial for Crohn's Disease HeatherAdministrator   02/10/04 01:30 PM
. * 5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer HeatherAdministrator   02/10/04 01:29 PM
. * Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis HeatherAdministrator   01/26/04 03:33 PM
. * Bone Disease and Intestinal Problems May Share a Common Cause HeatherAdministrator   01/07/04 11:47 AM
. * Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease HeatherAdministrator   12/16/03 11:59 AM
. * Environmental Factors May Play a Role in the Pathogenesis of IBD HeatherAdministrator   12/01/03 05:56 PM
. * Colonoscopy Prep HeatherAdministrator   10/17/03 12:05 PM
. * Detection of Pulmonary Involvement in Inflammatory Bowel Disease HeatherAdministrator   09/30/03 01:20 PM
. * Indeterminate Colitis HeatherAdministrator   09/16/03 03:33 PM
. * Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease HeatherAdministrator   09/16/03 03:30 PM
. * Bacteria in Milk Linked to Crohn's Disease and Possibly IBS HeatherAdministrator   08/12/03 11:55 AM
. * Inflammatory Bowel Disease During Pregnancy. HeatherAdministrator   07/15/03 06:20 PM
. * A study of the menopause, smoking, and contraception in women with Crohn's disease. HeatherAdministrator   07/15/03 06:05 PM
. * Hormone replacement therapy prevents bone loss in patients with IBD HeatherAdministrator   07/15/03 06:02 PM
. * Chemo Drug Improves Crohn's Symptoms HeatherAdministrator   07/14/03 04:09 PM

Extra information
0 registered and 7 anonymous users are browsing this forum.

Moderator:  Heather 



Permissions
      You cannot post until you login
      You cannot reply until you login
      HTML is enabled
      UBBCode is enabled

Thread views: 225195

Jump to

| Privacy statement Help for IBS Home

*
UBB.threads™ 6.2


Shop For IBS Here!