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Study on the efficacy of Lactobacillus in patients with irritable bowel syndrome.       07/18/03 11:42 AM Edit Reply Quote Heather Reged: 12/09/02 Posts: 7799 Loc: Seattle, WA Eur J Gastroenterol Hepatol. 2001 Oct;13(10):1143-7. A controlled, double-blind, randomized study on the efficacy of Lactobacillus plantarum 299V in patients with irritable bowel syndrome. Niedzielin K, Kordecki H, Birkenfeld B. Department of Gastroenterology, M. Curie Regional Hospital, Szczecin, Poland. Krzysztof.Niedzielin@mepha.com.pl BACKGROUND: Irritable bowel syndrome (IBS) is a widespread functional disorder of the digestive tract. Its aetiology is unknown and therapeutic options are limited. Recent reports suggest that probiotics may have a role in regulating the motility of the digestive tract. AIM: To assess the efficacy of Lactobacillus plantarum 299V (LP299V) in patients with IBS. PATIENTS AND METHODS: Forty patients were randomized to receive either LP299V in liquid suspension (20 patients) or placebo (20 patients) over a period of 4 weeks. Clinical examination was performed at baseline and at the end of the study. Additionally, patients assessed their symptoms by applying a scoring system. RESULTS: All patients treated with LP299V reported resolution of their abdominal pain as compared to 11 patients from a placebo group (P = 0.0012). There was also a trend towards normalization of stools frequency in constipated patients in six out of 10 patients treated with LP299V compared with two out of 11 treated with placebo (P = 0.17). With regards to all IBS symptoms an improvement was noted in 95% of patients in the LP299V group vs 15% of patients in the placebo group (P < 0.0001). CONCLUSIONS: LP299V seems to have a beneficial effect in patients with IBS. Further studies on larger cohorts of patients and with longer duration of therapy are required in order to establish the place of L. plantarum in the treatment of IBS. Publication Types: Clinical Trial Randomized Controlled Trial PMID: 11711768 [PubMed - indexed for MEDLINE] web page -------------------- Heather is the Administrator of the IBS Message Boards. She is the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook! Print     Remind Me     Notify Moderator

Entire thread Herbs, Probiotics, and Supplements Heather 07/14/03 01:53 PM Western herbal medicines in the treatment of irritable bowel syndrome: A systematic review and meta-analysis Heather 11/11/20 02:53 PM Medical cannabis: Promising uses supported by medical data Heather 03/05/19 12:58 PM Glutamine supplements improve symptoms of postinfectious IBS-Diarrhea Heather 08/22/18 02:35 PM Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome Heather 01/26/18 12:06 PM Vitamin D deficiency in children and adults with IBS Heather 04/07/17 03:18 PM Trial of aloe vera for irritable bowel syndrome Heather 05/27/15 02:44 PM Aloe vera in Patients with Irritable Bowel Syndrome Heather 05/27/15 02:39 PM Vitamins and IBS Heather 03/11/14 02:10 PM IBS Quick Tip - Aloe, Senna, and Cascara for IBS? Heather 09/10/13 11:20 AM IBS quick tip -taking a fiber supplements and medications Heather 08/30/13 11:54 AM Fennel is an effective herbal drug for menstrual pain Heather 08/21/13 05:59 PM Probiotic treatments relieve irritable bowel syndrome symptoms in recent study Heather 01/18/13 02:38 PM Probiotics for GI Issues and Obesity - Problems May Take Root in Gut Flora Heather 05/09/12 01:26 PM Probiotics May Prevent Antibiotic Diarrhea Heather 05/09/12 12:38 PM Today Show Recommends Peppermint Oil Caps for IBS Heather 12/02/11 03:58 PM Dr. Oz Recommends Peppermint Oil Capsules Heather 11/23/11 02:32 PM Probiotic Pills Better for IBS than Yogurt Heather 09/30/11 12:06 PM How Peppermint Helps to Relieve Irritable Bowel Syndrome Heather 04/20/11 12:41 PM Zinc for acute diarrhea Heather 02/10/11 10:18 AM Effect of ginger on gastric motility and symptoms of functional dyspepsia Heather 02/10/11 10:16 AM Inulin can cause gastrointestinal discomfort Heather 07/16/10 03:13 PM St. John's Wort Not Helpful For Irritable Bowel Syndrome Heather 01/08/10 02:19 PM Systematic Review and Meta-Analysis: Probiotics in the treatment of Irritable Bowel Syndrome Heather 02/18/09 02:16 PM Probiotic Yogurt Helps Reduce Physical Bloating Heather 12/16/08 11:40 AM Peppermint oil, soluble fiber, and antispasmodics should be first-line treatments Heather 12/03/08 11:37 AM Health Benefits of Probiotic Could Extend Beyond Gastrointestinal System Heather 08/27/08 12:24 PM Acacia establishes prebiotic functionality in healthy human volunteers Heather 06/19/08 11:54 AM Probiotics and prebiotics in irritable bowel syndrome Heather 06/06/08 09:41 AM Gastrointestinal Microbiota in Irritable Bowel Syndrome Heather 06/05/08 03:56 PM Efficacy of Probiotics in Irritable Bowel Syndrome Heather 05/23/08 11:06 AM Probiotics in irritable bowel syndrome Heather 01/18/08 12:32 PM Bacteria: a new player in gastrointestinal motility disorders-infections, bacterial overgrowth, and probiotics Heather 11/07/07 02:49 PM Probiotic-prebiotic treatment for irritable bowel syndrome Heather 08/28/07 01:29 PM Peppermint oil is effective in treating digestive disorders and other conditions including headaches Heather 06/06/07 11:20 AM Probiotics and irritable bowel syndrome Heather 05/11/07 02:25 PM Bacterial flora in irritable bowel syndrome Heather 05/11/07 02:19 PM Peppermint oil capsules in the treatment of irritable bowel syndrome Heather 04/28/07 10:36 AM Probiotics in women with IBS Heather 02/04/07 04:17 PM Comparison of fennel and the drug mefenamic acid on pain intensity of menstrual cramps Heather 12/01/06 02:27 PM Probiotics Effective for Treating Clostridium Difficile Disease and Antibiotic-Associated Diarrhea? Heather 12/01/06 01:09 PM Review of Probiotics for IBD Heather 07/17/06 02:10 PM A review of the bioactivity and potential health benefits of peppermint tea Heather 07/17/06 12:01 PM Probiotics Help Chronic Constipation Heather 07/05/06 05:40 PM Beneficial Bacteria Protect the Gut from Stress Heather 05/29/06 02:25 PM Dietary fibre supplementation with psyllium or Acacia (gum arabic) reduced faecal incontinence Heather 05/29/06 02:23 PM Probiotics and chronic disease Heather 05/13/06 03:23 PM Peppermint Oil May Be "Drug of First Choice" for IBS Heather 03/16/06 12:45 PM Herbal medicines for treatment of irritable bowel syndrome Heather 02/18/06 12:54 PM Peppermint possesses antispasmodic properties Heather 12/21/05 11:16 AM Pharmacological Basis for the Medicinal Use of Ginger in Gastrointestinal Disorders Heather 12/19/05 04:50 PM Probiotic relieves irritable bowel syndrome Heather 11/12/05 01:04 PM Melatonin May Reduce the Pain of Irritable Bowel Syndrome Heather 10/28/05 11:53 AM A probiotic mixture alleviates symptoms in irritable bowel syndrome patients Heather 09/22/05 04:26 PM Interactions Between Commensal Bacteria and Gut Sensorimotor Function Heather 08/22/05 04:57 PM Prebiotic shown to increase bone mineral density Heather 06/05/05 05:40 PM Fiber's New Role in Type 2 Diabetes Heather 06/05/05 05:28 PM "Good" Bacteria Help Irritable Bowel Syndrome as much as Zelnorm and Lotronex Heather 04/10/05 06:34 PM Complementary and Alternative Medicine Use by Patients With Gastrointestinal Diseases. Heather 01/23/05 04:56 PM New evidence supports camomile tea's health benefits Heather 01/07/05 05:02 PM Effectiveness of a symbiotic preparation in irritable bowel syndrome Heather 11/08/04 04:44 PM Probiotic VSL#3 Could Relieve Some Irritable Bowel Abdominal Bloating Heather 11/08/04 04:04 PM Probiotic Improves Postinfective Gut Dysfunction in Animal Model Heather 10/11/04 04:30 PM Probiotics, dead or alive, can relieve gut disease Heather 08/30/04 02:38 PM Prebiotics for improved gut health Heather 07/11/04 03:15 PM Calcium Seems to Protect Against Colorectal Cancer Heather 06/27/04 02:04 PM Safety of aloe a concern Heather 05/25/04 03:26 PM Aloe, cascara sagrada, and senna laxtives can cause cathartic colon Heather 05/25/04 03:24 PM Gut Check - The bacteria in your intestines are welcome guests Heather 05/10/04 01:33 PM Probiotics and Prebiotics in Gastrointestinal Disorders Heather 04/27/04 08:53 PM Yogurt Prevents Antibiotic-Associated Diarrhea Heather 04/13/04 02:50 PM Bacteria Basics - Probiotics for IBS and IBD Heather 03/30/04 01:56 PM Lactobacillus Reduces Irritable Bowel Bloating Heather 12/01/03 06:06 PM Probiotic improves gastrointestinal symptoms in patients with chronic constipation Heather 12/01/03 06:00 PM Aloe plant's IBS healing powers tested Heather 11/18/03 03:42 PM Possible Drug Interactions with: Ginger Heather 10/13/03 01:19 PM Hepatoprotective effect of Fennel essential oil Heather 10/12/03 04:53 PM Fennel for the treatment of primary dysmenorrhea Heather 10/12/03 04:51 PM Fennel, intestinal spasms, and infantile colic Heather 10/12/03 04:48 PM Probiotics Significantly Reduce Symptoms of IBS, Ulcerative Colitis Heather 07/22/03 09:41 PM Ginger: history and use for the prevention of nausea, dizziness, and vomiting Heather 07/22/03 06:52 PM Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Heather 07/22/03 06:50 PM Alteration of intestinal microflora and reduced IBS bloating and pain Heather 07/18/03 12:01 PM Study on the efficacy of Lactobacillus in patients with irritable bowel syndrome. Heather 07/18/03 11:42 AM Treatment for constipation-predominant IBS using Padma Lax, a Tibetan herbal formula Heather 07/15/03 11:24 PM Ginger for nausea and vomiting in pregnancy Heather 07/14/03 03:55 PM Peppermint-oil capsules in the treatment of IBS: a prospective, randomized trial Heather 07/14/03 03:51 PM Efficacy of Peppermint oil in diarrhea predominant IBS Heather 08/21/13 05:44 PM The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Heather 08/21/13 05:46 PM Peppermint oil capsules for the treatment of IBS in children. Heather 07/14/03 03:49 PM

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