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Syl

Reged: 03/13/05
Posts: 5495
Loc: SK, CANADA
Looking at the full paper ...
      05/30/12 03:00 PM

it says "Of the initial 320 subjects, 112 were IBS sufferers; 35 patients (31.2%) had IBS-D; 19 patients (16.9%) had IBSC; and 58 patients (51.8%) had IBS-A."

518 patients were screened and 320 subjects were enrolled if the met the inclusion criteria stated as "Inclusion criteria were: (a) age C18 years, and (b) clinical indication for outpatient upper GI tract endoscopy." There were a variety exclusion criteria including such things as recent antibiotic use, HIV and hypothyroidism. In other words, individuals were not enrolled solely because they had IBS or SIBO. They were enrolled because they were having an endoscopy.

"Before undergoing upper GI tract endoscopy, patients were asked to provide replies to a specific questionnaire trying to disclose the presence of IBS." The ROME II criteria was used to diagnosis enrolled individuals for IBS.

"Of the initial 320 subjects, 112 were IBS sufferers; 35 patients (31.2%) had IBS-D; 19 patients (16.9%) had IBSC; and 58 patients (51.8%) had IBS-A. Reasons for upper GI tract endoscopy among IBS patients were dyspepsia in 75 patients (66.9%), anemia in 24 patients (21.4%) and change of bowel frequency in nine patients (8.0%); the remaining patients had a list of other uncommon complaints."

During the endoscopy fluid samples were taken from 3rd part of the duodenum and cultured. "The most common bacterial species isolated from the duodenal aspirate of the 62 atients with SIBO were Escherichia coli (n = 23; 37.1%), Enterococcus spp (n = 20; 32.3%), Klebsiella pneumoniae (n = 15; 24.2%), Proteus mirabilis (n = 4; 6.5%), Acinetobacter baumannii (n = 3; 4.8%), Citrobacter freundii (n = 3; 4.8%), Serratia marscecens (n = 3; 4.8%), Staphylococcus aureus (n = 2; 2.9%), Pseudomonas putida (n = 2; 2.9%), Pasteurella multocida (n = 2; 2.9%) and Enterobacter aerogenes (n = 1; 1.6%)."

"Among these IBS subjects, 42 (37.5%) met the applied definition for SIBO." So of the 360 enrolled individuals 112 had IBS according to the ROME criteria and 37.5% of these meet the definition of SIBO. And "The frequency of SIBO was much greater among patients with IBS-D. More precisely, 33.8% of patients with SIBO were sufferers of IBS-D compared with 5.4% of patients without SIBO (P\0.0001) (Table 1)."

"Examining the relationship between SIBO and IBS, among the 62 patients with SIBO, 42 had IBS (67.7%). This was greater than the 258 patients without SIBO, whereby only 70 had IBS (27.1%) (Mantel–Haenszel common odds ratio estimate: 5.64; 95% CI 3.09–10.27; P\0.0001)."

This is not "definitive" evidence that bacteria can play a role in IBS. Given no methodological errors it is strong evidence that in a subset of individuals diagnosed with IBS using the ROME II criteria, particularly those with IBS-D, that bacteria likely plays a role.


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The FODMAP Approach to Managing IBS Symptoms
Evidence-based Dietary Management of Functional GI Symptoms: The FODMAP Approach
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The Role of Food & Dietary Intervention in IBS

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Entire thread
Subject Posted by Posted on
* Irritable Bowel Linked To Gut Bacteria, Definitively capricorn1942 05/30/12 04:34 AM
. * This is so interesting, HeatherAdministrator   05/30/12 11:56 AM
. * Re: This is so interesting, maggles   06/18/13 02:48 PM
. * Thanks Maggie! I am SO glad you finally got this test HeatherAdministrator   06/18/13 05:16 PM
. * Re: Thanks Maggie! I am SO glad you finally got this test Roxstar   06/27/13 10:08 PM
. * Re: Thanks Maggie! I am SO glad you finally got this test Syl   06/28/13 07:03 AM
. * Looking at the full paper ... Syl   05/30/12 03:00 PM
. * Re: Looking at the full paper ... capricorn1942   05/31/12 06:55 AM
. * Re: Looking at the full paper ... Syl   05/31/12 07:31 AM
. * Re: Looking at the full paper ... capricorn1942   06/01/12 04:36 AM
. * Re: Looking at the full paper ... Syl   06/01/12 05:09 AM
. * Re: Looking at the full paper ... capricorn1942   06/01/12 05:40 AM
. * Re: Looking at the full paper ... Syl   06/01/12 07:30 AM
. * Re: Looking at the full paper ... capricorn1942   06/02/12 06:12 AM
. * I'd like to see the people with SIBO screened out HeatherAdministrator   05/30/12 03:56 PM
. * Re: I'd like to see the people with SIBO screened out Syl   05/30/12 05:58 PM
. * Re: I'd like to see the people with SIBO screened out bg   06/26/12 08:18 PM
. * Celiac disease Syl   06/27/12 04:36 AM
. * Re: Celiac disease bg   07/06/12 09:13 PM
. * Re: Celiac disease Clifton   06/28/12 04:51 AM
. * Re: Celiac disease Syl   06/28/12 05:05 AM
. * Re: Celiac disease Clifton   07/03/12 05:01 AM
. * Re: I'd like to see the people with SIBO screened out KellyJean   05/31/12 09:43 AM

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