Quote: I've tried many with failure. Which ones have you tried? Are you C or D? I assume a C since you mentioned Zelnorm.
It makes a big difference because the side effects often cause either C or D to worsen.
Yes, I have C. The most recent ones I have tried are Cymbalta gave me a horrible Stomach ache. Effexor Stomach ache. This is just after taking one tablet. Now I'm going to try Lexapro again which I took 6 years ago & it made me ill then. I had this same headache/chest pain(did not have IBS @ the time)6 yrs ago I had it for 2 years before I found any help & that was Celexa. I took Celexa for 1 year (best thing ever for me) but I broke out & stopped taking it. They then put me on Lexapro which gave me a Stomach ache. So went off entirely. Stayed well(headache/chest pain)for 3 years now I'm sick again & also have isommonia. I think I'm just about out of luck! I may have to try Celexa again because my Doc said people usually have reactions right away so it may have been something else that made me break out. Wish me luck tonight with the Lexapro! Do you have other health problems also or just IBS? The IBS alone is enough to make you depressed having other things is horrible!