I'm sorry you're suffering so much! In the past ten years, I've had two times where I was in so much pain and discomfort, becoming obsessed with what I ate and afraid to leave the house, that I thought, "Is this my life from now on?" I worried what people thought of me, I cried about what I was missing out on as a young woman. But there's hope! I know you've heard it before, but it does take time and experimenting with different foods and meds. Everyday you just have to grasp onto something good, even if it seems insignificant.
One thing you might ask your doctor is if you could have a parasite; sometimes they get missed in a stool sample or are in your small intestine (I don't think a colonoscopy would detect this then), like giardia, and they could be causing you to lose weight, the nausea, etc. You might have another stool sample done or talk to your doctor about whether there was a possibility you were exposed.
Something that might encourage your body to "normalize" is to eat at the same time everyday. For a year, I experimented with food and meds. The meds I was on, antidepressant + antispasmodic + antidiarrheal, just seemed to make me feel worse. I'd go from D to seriously C for a couple of weeks and then back to horrible, burning D. I decided to quit the antidepressant, since I wasn't feeling better anyway, and started using the antispasmodic and antidiarrheal only as needed. This was a personal choice, you should always talk to your doctor before changing or stopping meds.
But it wasn't until I started eating on a schedule, following the IBS diet, that good changes started happening. I ate breakfast, lunch, and dinner and snacks around the same time everyday. I didn't eat after 7 pm or have drinks with meals. I also took a fiber supplement (about twice a day between meals) and peppermint or chamomile tea with a couple of drops of anise oil after meals (for gas or colic and cramps). What this did was regulate my bm's, so even though they were still painful and loose, at least I knew when they were coming. I also made sure to get plenty of sleep or at least be in bed early, relaxing and reading or watching TV. And light yoga or walking, as the others mentioned, is great for stress relief. I think just getting outside makes you feel a little better. After a while (about three months), I stopped having the diarrhea and when I did it was when I strayed from the schedule/diet or due to an increase in stress.
I still have times when I'm not doing so well. I was really sick this past fall and, lately, I've been dealing with anxiety, which is why I finally joined this board after reading it for months. It's good to have people you can talk to, who understand, and who aren't grossed out by stool talk. 
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Re: Totally lost (long reply)
