10/11/04 04:30 PM
Probiotic Improves Postinfective Gut Dysfunction in Animal Model

Probiotic Improves Postinfective Gut Dysfunction in Animal Model

NEW YORK (Reuters Health) Sept 22 - Treatment with the probiotic Lactobacillus paracasei reduces the muscle hypercontractility seen in an animal model of postinfective gut dysfunction, suggesting a possible benefit for patients with postinfective irritable bowel syndrome (IBS), new research shows.

The findings, which appear in the September issue of Gastroenterology, are based on a study of mice that developed gut dysfunction after being infection with Trichinella spiralis. The animals were then treated with various active or heat-inactivated probiotics.

Treatment with L. paracasei several days after infection attenuated the muscle hypercontractility normally seen, lead author Dr. Elena F. Verdu, from McMaster University in Hamilton, Canada, and colleagues note. In contrast, other probiotics, such as L. johnsonii, Bifidobacterium lactis, and B. longum, had no effect.

Further analysis revealed that L. paracasei's effect was associated with a drop in the T. spiralis-related T-helper 2 response and with a reduction in muscle levels of TGF-beta1, cyclooxygenase-2, and prostaglandin E2.

"To our knowledge, no studies have been performed on the effect of probiotics in patients with postinfective IBS," the authors state. "Our results raise the possibility that L. paracasei could be useful in attenuating postinfective gut dysfunction in humans and in treating postinfective IBS."

Gastroenterology 2004;127:826-837.


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