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All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7655
Loc: Seattle, WA
Zinc for acute diarrhea
      02/10/11 10:18 AM

Current Opinion in Gastroenterology:
January 2011 - Volume 27 - Issue 1 - p 8–12
doi: 10.1097/MOG.0b013e32833fd48a
Gastrointestinal infections: Edited by Mitchell B. Cohen

Mechanisms of action of zinc in acute diarrhea

Berni Canani, Robertoa,b; Buccigrossi, Vittoriaa; Passariello, Annalisaa,c


Purpose of review: For over a decade, the importance of zinc in the treatment of acute diarrhea has been recognized.

More recently, the mechanisms of action of zinc are becoming clearer. This review is focused on the new evidence on the mechanisms of action of zinc in acute diarrhea.

Recent findings: The vast majority of data derive from in-vitro studies using intestinal cell lines or from animal model. The positive action by zinc in acute diarrhea derives from a regulation of intestinal fluid transport, mucosal integrity, immunity, gene expression, and oxidative stress. A complex homeostatic network is also able to regulate zinc status at cellular and extracellular level.

Summary: All these data support the use of zinc in the treatment of acute diarrhea, but further clinical studies are needed to explore the selective effects of zinc against specific pathogens responsible for diarrhea.

http://journals.lww.com/co-gastroenterology/Abstract/2011/01000/Mechanisms_of_action_of_zinc_in_acute_diarrhea.3.aspx

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Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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