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All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7422
Loc: Seattle, WA
Accutane may cause ulcerative colitis
04/09/10 01:38 PM

NEW YORK (Reuters Health) - Adding to evidence that the acne drug isotretinoin may lead to bowel disease in some users, a new study finds that patients on the medication were four times more likely than non-users to develop ulcerative colitis within a year.

Reporting in the American Journal of Gastroenterology, researchers say that the risk of any one isotretinoin user developing ulcerative colitis is "likely quite small."

However, the findings do strengthen the evidence of a cause-and-effect relationship between the acne drug and inflammatory bowel disease (IBD) -- a group of digestive disorders that includes ulcerative colitis and Crohn's disease.

Isotretinoin, which is used to treat severe acne, is probably best known by the brand-name Accutane. That drug was taken off the market last year in the face of competition from generic alternatives -- though in pulling the medication, maker Roche Pharmaceuticals also cited costs from defending personal-injury lawsuits.

Earlier this year, the company was ordered to pay $25 million in damages to a former Accutane user who claimed that the drug caused his IBD.

The company has maintained that there is no strong evidence that the acne drug triggers IBD. Between 1997 and 2002, 83 cases of IBD among isotretinoin users were reported to the U.S. Food and Drug Administration, but that does not prove that the drug itself is to blame.

For the new study, Dr. Seth D. Crockett and colleagues at the University of North Carolina Chapel Hill tried to test the cause-and-effect relationship.

Using a database of information from 87 U.S. health insurance plans, the researchers identified 8,189 people -- mostly adults -- who'd been diagnosed with IBD. They then compared each of those individuals with up to three other health plan members the same age and sex with no history of IBD.

Of the nearly 8,200 IBD patients, Crockett's team found, 24 had used isotretinoin in the year before diagnosis; and of the nearly 22,000 controls, 36 had used the acne drug over a one-year period.

Overall, the researchers found, isotretinoin users were roughly four times more likely than non-users to have ulcerative colitis. There was no association, however, between isotretinoin use and Crohn's disease.

The researchers also found that the risk of ulcerative colitis tended to climb in tandem with patients' daily dose of the drug -- which strengthens the case for a cause-and-effect relationship. There was no evidence that severe acne itself was linked to IBD risk.

Still, the findings do not definitively prove that isotretinoin was the cause of some patients' ulcerative colitis, and the researchers say that further studies are needed to confirm their results.

If the acne drug does lead to ulcerative colitis in some cases, the absolute risk of that happening to any one patient are probably quite small, Crockett and his colleagues point out. But, they add, patients with severe acne should be aware of the possible link between isotretinoin and IBD before they are prescribed the drug.

The biological mechanism by which isotretinoin might contribute to IBD is not clear, but some researchers have speculated that the drug may affect immune function in the intestines. Both Crohn's disease and ulcerative colitis are thought to involve abnormal immune system activity.

As for why isotretinoin was linked to ulcerative colitis, but not Crohn's, in this study, Crockett and his colleagues point out that while the two disorders are related, they are distinct and have different immune-system-related features.

SOURCE: here 4a.html American Journal of Gastroenterology, online March 30, 2010.

Thomson Reuters 2010 All rights reserved.

http://uk.reuters.com/article/idUKTRE6354OK20100406?sp=true

--------------------
Heather is the Administrator of the IBS Message Boards. Shes the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Subject Posted by Posted on
* Inflammatory Bowel Disease HeatherAdministrator 07/14/03 01:51 PM
. * Hormonal contraception improved menstrual-related IBD symptoms HeatherAdministrator 09/15/14 12:43 PM
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. * Inflammatory Bowel Disease: Heat Waves Linked to Flares HeatherAdministrator 08/16/13 12:58 PM
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. * Genetic Clues May Help Unravel Cause of Crohn's HeatherAdministrator 11/02/12 12:59 PM
. * Inflammatory bowel, ulcerative colitis linked to intestinal fungi HeatherAdministrator 06/15/12 01:23 PM
. * Smoking makes Crohn's disease worse HeatherAdministrator 05/09/12 01:33 PM
. * Kids With Crohns Disease, Colitis Often Struggle at School HeatherAdministrator 04/23/12 01:22 PM
. * As Nations Develop, So May Bowel Disease HeatherAdministrator 01/09/12 12:01 PM
. * Loneliness Triggers Inflammatory Illnesses HeatherAdministrator 02/10/11 10:05 AM
. * Infants' antibiotic use tied to IBD risk HeatherAdministrator 11/03/10 01:42 PM
. * Olive Oil May Protect Against Ulcerative Colitis HeatherAdministrator 05/05/10 10:32 AM
. * Accutane may cause ulcerative colitis HeatherAdministrator 04/09/10 01:38 PM
. * Red meat may raise odds for ulcerative colitis, but oily fish could be protective HeatherAdministrator 03/11/10 01:22 PM
. * Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified? HeatherAdministrator 01/05/10 12:03 PM
. * Novel Compound Targets Mucosal Healing in Crohn's HeatherAdministrator 05/29/06 02:19 PM
. * Viagra May Help Crohn's Disease HeatherAdministrator 03/04/06 12:50 PM
. * Carbon Monoxide Eases Ulcerative Colitis HeatherAdministrator 01/18/06 04:12 PM
. * Colonoscopic Surveillance in Inflammatory Bowel Disease HeatherAdministrator 10/11/05 01:33 PM
. * Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease HeatherAdministrator 09/13/05 01:22 PM
. * Cannabinoids Show Promise for Inflammatory Bowel Disease HeatherAdministrator 09/01/05 11:23 AM
. * Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome HeatherAdministrator 09/01/05 11:13 AM
. * The Clinical Epidemiology of Inflammatory Bowel Disease HeatherAdministrator 08/22/05 04:45 PM
. * IBD Patients May Benefit From Folic Acid Supplementation HeatherAdministrator 05/22/05 07:02 PM
. * Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis HeatherAdministrator 04/24/05 03:33 PM
. * Biotic Therapy Cuts Inflammation in Ulcerative Colitis HeatherAdministrator 02/19/05 05:59 PM
. * Calming Crohn's Disease with Fish Oil and Antioxidants HeatherAdministrator 01/07/05 04:55 PM
. * Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis HeatherAdministrator 12/20/04 01:37 PM
. * Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden? HeatherAdministrator 11/28/04 02:58 PM
. * Diet May Influence Relapse in Ulcerative Colitis HeatherAdministrator 10/24/04 07:50 PM
. * Parasite Therapy for Crohn's and Colitis? HeatherAdministrator 08/08/04 03:00 PM
. * Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases HeatherAdministrator 06/04/04 06:41 PM
. * Faulty Gene for Crohn's Disease Found HeatherAdministrator 04/13/04 03:19 PM
. * Data links Crohn's disease and antibiotics HeatherAdministrator 02/24/04 02:07 PM
. * Elan Reports Successful Results of Antegren Trial for Crohn's Disease HeatherAdministrator 02/10/04 01:30 PM
. * 5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer HeatherAdministrator 02/10/04 01:29 PM
. * Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis HeatherAdministrator 01/26/04 03:33 PM
. * Bone Disease and Intestinal Problems May Share a Common Cause HeatherAdministrator 01/07/04 11:47 AM
. * Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease HeatherAdministrator 12/16/03 11:59 AM
. * Environmental Factors May Play a Role in the Pathogenesis of IBD HeatherAdministrator 12/01/03 05:56 PM
. * Colonoscopy Prep HeatherAdministrator 10/17/03 12:05 PM
. * Detection of Pulmonary Involvement in Inflammatory Bowel Disease HeatherAdministrator 09/30/03 01:20 PM
. * Indeterminate Colitis HeatherAdministrator 09/16/03 03:33 PM
. * Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease HeatherAdministrator 09/16/03 03:30 PM
. * Bacteria in Milk Linked to Crohn's Disease and Possibly IBS HeatherAdministrator 08/12/03 11:55 AM
. * Inflammatory Bowel Disease During Pregnancy. HeatherAdministrator 07/15/03 06:20 PM
. * A study of the menopause, smoking, and contraception in women with Crohn's disease. HeatherAdministrator 07/15/03 06:05 PM
. * Hormone replacement therapy prevents bone loss in patients with IBD HeatherAdministrator 07/15/03 06:02 PM
. * Chemo Drug Improves Crohn's Symptoms HeatherAdministrator 07/14/03 04:09 PM

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