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Heather

Reged: 12/09/02

Posts: 7080

Loc: Seattle, WA

Bone Disease and Intestinal Problems May Share a Common Cause
01/07/04 11:47 AM

By Megan Rauscher

NEW YORK (Reuters Health) Dec 26 - Scientists have evidence in mice that osteoporosis-like bone disorders and inflammatory intestinal disorders are both caused by abnormal regulation of a common protein.

Dr. Simon R. Carding from the University of Leeds in England and colleagues report their study in the December issue of the journal Immunity. "Autoimmune associated bone disease and intestinal inflammation are closely linked with deregulation and hyperactivation of autoreactive CD4 T cells," they write. "How these T cells are activated and mediate disease is not clear."

Mice engineered to lack a key regulator of CD4 T cells have overactive T cells and spontaneously develop ulcerative colitis and osteopenia, the scientists explain. Dr. Carding and colleagues' experiments indicate that this is caused by increased production of the ligand for receptor activator of NFkB (RANKL).

"We find that the hyperactive CD4 T cells produce too much of this protein, which then contributes to bone breakdown and bowel inflammation," Dr. Carding said.

Treating mice with exogenous recombinant osteoprotegerin -- a protein that interferes with RANKLs binding to its receptor -- reversed bone loss and improved colitis.

"This study shows that some bone diseases and intestinal problems may share a common cause," Dr. Carding told Reuters Health. "If similar mechanisms occur in humans, then osteoprotegerin might prove a useful treatment for intestinal disorders such as ulcerative colitis and Crohn's disease," he said, which are both often accompanied by bone loss.

Immunity 2003;19:849-861.

http://www.medscape.com/viewarticle/466447?mpid=23090

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Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Subject	Posted by	Posted on
Inflammatory Bowel Disease	Heather	07/14/03 01:51 PM
Genetic Clues May Help Unravel Cause of Crohn's	Heather	11/02/12 12:59 PM
Inflammatory bowel, ulcerative colitis linked to intestinal fungi	Heather	06/15/12 01:23 PM
Smoking makes Crohn's disease worse	Heather	05/09/12 01:33 PM
Kids With Crohn’s Disease, Colitis Often Struggle at School	Heather	04/23/12 01:22 PM
As Nations Develop, So May Bowel Disease	Heather	01/09/12 12:01 PM
Loneliness Triggers Inflammatory Illnesses	Heather	02/10/11 10:05 AM
Infants' antibiotic use tied to IBD risk	Heather	11/03/10 01:42 PM
Olive Oil May Protect Against Ulcerative Colitis	Heather	05/05/10 10:32 AM
Accutane may cause ulcerative colitis	Heather	04/09/10 01:38 PM
Red meat may raise odds for ulcerative colitis, but oily fish could be protective	Heather	03/11/10 01:22 PM
Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified?	Heather	01/05/10 12:03 PM
Novel Compound Targets Mucosal Healing in Crohn's	Heather	05/29/06 02:19 PM
Viagra May Help Crohn's Disease	Heather	03/04/06 12:50 PM
Carbon Monoxide Eases Ulcerative Colitis	Heather	01/18/06 04:12 PM
Colonoscopic Surveillance in Inflammatory Bowel Disease	Heather	10/11/05 01:33 PM
Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease	Heather	09/13/05 01:22 PM
Cannabinoids Show Promise for Inflammatory Bowel Disease	Heather	09/01/05 11:23 AM
Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome	Heather	09/01/05 11:13 AM
The Clinical Epidemiology of Inflammatory Bowel Disease	Heather	08/22/05 04:45 PM
IBD Patients May Benefit From Folic Acid Supplementation	Heather	05/22/05 07:02 PM
Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis	Heather	04/24/05 03:33 PM
Biotic Therapy Cuts Inflammation in Ulcerative Colitis	Heather	02/19/05 05:59 PM
Calming Crohn's Disease with Fish Oil and Antioxidants	Heather	01/07/05 04:55 PM
Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis	Heather	12/20/04 01:37 PM
Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden?	Heather	11/28/04 02:58 PM
Diet May Influence Relapse in Ulcerative Colitis	Heather	10/24/04 07:50 PM
Parasite Therapy for Crohn's and Colitis?	Heather	08/08/04 03:00 PM
Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases	Heather	06/04/04 06:41 PM
Faulty Gene for Crohn's Disease Found	Heather	04/13/04 03:19 PM
Data links Crohn's disease and antibiotics	Heather	02/24/04 02:07 PM
Elan Reports Successful Results of Antegren Trial for Crohn's Disease	Heather	02/10/04 01:30 PM
5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer	Heather	02/10/04 01:29 PM
Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis	Heather	01/26/04 03:33 PM
Bone Disease and Intestinal Problems May Share a Common Cause	Heather	01/07/04 11:47 AM
Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease	Heather	12/16/03 11:59 AM
Environmental Factors May Play a Role in the Pathogenesis of IBD	Heather	12/01/03 05:56 PM
Colonoscopy Prep	Heather	10/17/03 12:05 PM
Detection of Pulmonary Involvement in Inflammatory Bowel Disease	Heather	09/30/03 01:20 PM
Indeterminate Colitis	Heather	09/16/03 03:33 PM
Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease	Heather	09/16/03 03:30 PM
Bacteria in Milk Linked to Crohn's Disease and Possibly IBS	Heather	08/12/03 11:55 AM
Inflammatory Bowel Disease During Pregnancy.	Heather	07/15/03 06:20 PM
A study of the menopause, smoking, and contraception in women with Crohn's disease.	Heather	07/15/03 06:05 PM
Hormone replacement therapy prevents bone loss in patients with IBD	Heather	07/15/03 06:02 PM
Chemo Drug Improves Crohn's Symptoms	Heather	07/14/03 04:09 PM

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