Help For Irritable Bowel Syndrome (IBS) - Education, Support, & Self Help for Irritable Bowel Syndrome   
Heather & Company View Cart  
Shop for IBSIBS Message BoardsIBS News & ReviewsStore Finder  
IBS Diet & Recipes
IBS Books
IBS Supplements
Yoga for IBS
Hypnosis for IBS
Tummy Teas

All Boards >> Irritable Bowel Syndrome Research Library


Reged: 12/09/02
Posts: 7389
Loc: Seattle, WA
Genetic factors may play a role in IBS
      09/26/08 02:52 PM

Researchers at Mayo Clinic studying irritable bowel syndrome say their study of people with this disorder suggests genetic factors may play a role.

Irritable bowel syndrome is a common problem affecting about one in 10 adults. However, many people don’t talk about irritable bowel syndrome, which causes abdominal cramping, constipation and diarrhea. The study, which is published in the December issue of Gut, an international journal in gastroenterology, shows that the risk of having irritable bowel syndrome is nearly double in the families of people with the disorder.

“The next challenge is determining nature versus nurture,” said G. Richard Locke, M.D., a Mayo Clinic gastroenterologist and one of the authors of the study. “Is this due to a gene or genes or is it due to a shared environmental factor? Our group is active in investigating these issues.”

In developing the study, researchers noted that people with irritable bowel syndrome often report family members with similar symptoms. The researchers hypothesized that if there is a familial connection, there would be an increased frequency of irritable bowel syndrome in direct relatives of irritable bowel syndrome patients compared to relatives of people without irritable bowel syndrome.

Others who conducted the study include Jamshid Kalantar, M.D., Alan Zinsmeister, Ph.D., Christopher Beighley, and Nicholas Talley, M.D., Ph.D. Dr. Kalantar was a research fellow at Mayo Clinic during the study, but is now with the Department of Medicine, University of Sydney, Australia. Mr. Beighley now works in West Virginia. The others are with Mayo Clinic in Rochester.

In the study, patients with irritable bowel syndrome seen at Mayo Clinic and their spouses filled out a bowel disease questionnaire and provided the names and addresses of their direct relatives. Researchers then sent a bowel disease questionnaire to 355 relatives of the patients and their spouses, and 71 percent responded. Irritable bowel syndrome occurred in 17 percent of the patients’ relatives compared with 7 percent in spouses’ relatives.


Adapted from materials provided by Mayo Clinic.
MLA Mayo Clinic (2003, December 11). Irritable Bowel Syndrome's Possible Genetic Link Studied. ScienceDaily.

Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

Post Extras Print Post   Remind Me!     Notify Moderator

Entire thread
Subject Posted by Posted on
* General IBS / Bowel Dysfunction HeatherAdministrator 07/14/03 01:56 PM
. * Sleep Measures Can Help Predict Next-Day Symptoms in IBS Female Patients HeatherAdministrator   09/17/14 02:27 PM
. * Domestic violence may trigger irritable bowel syndrome HeatherAdministrator   09/17/14 02:15 PM
. * All IBS subtypes have similar symptom severity HeatherAdministrator   09/05/14 03:50 PM
. * Gut microbiome can diagnose colorectal cancer? HeatherAdministrator   08/12/14 11:21 AM
. * Sacral nerve stimulation does not help IBS HeatherAdministrator   07/15/14 02:57 PM
. * Small Study of IBS Patients Suggests Symptom Improvement with Fecal Microbiota Transplant HeatherAdministrator   06/27/14 04:15 PM
. * Vitamin D Role in Fecal Incontinence? HeatherAdministrator   05/22/14 05:03 PM
. * Colonic bile acid exposure influenced IBS symptoms HeatherAdministrator   05/22/14 04:50 PM
. * Good Vibration(s) for Constipation? HeatherAdministrator   05/12/14 03:55 PM
. * Can you give your spouse IBS? HeatherAdministrator   04/22/14 02:12 PM
. * Factors linked to chronic constipation HeatherAdministrator   04/07/14 02:06 PM
. * IBS patients' health perceptions focus on non-GI issues HeatherAdministrator   04/07/14 01:35 PM
. * Is IBS Funding a Joke? HeatherAdministrator   01/17/14 11:53 AM
. * Blood Test for IBS? HeatherAdministrator   10/16/13 01:30 PM
. *