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All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7671
Loc: Seattle, WA
Marijuana eases chronic pain
† † † 07/17/06 11:49 AM

Marijuana eases chronic pain, study finds

Cannabis extract from marijuana gives powerful relief for chronic pain, and should be studied for future clinical use, a medical researcher has told a conference in Glasgow.

Dr William Notcutt of the James Paget Hospital in Great Yarmouth, England, said the cannabis extract used in his study - applied as a spray under the tongue - was remarkably effective in easing chronic pain. He announced the findings at the annual meeting of the British Association for the Advancement of Science.

"The cannabis extracts can produce high-quality pain relief, symptom control, and improvement in the quality of life, without significant side effects," said Dr Notcutt.

He tested cannabis extracts collected from cloned plants, in 23 sufferers of chronic pain.

Subjects were mostly patients with multiple sclerosis or spinal injury. Nine had used marijuana regularly in the past, while the remainder were 'naÔve': they had either not used it at all, or had tried it infrequently.

The cannabinoid extract was given over eight weeks, and participants' pain levels monitored. Asked to rate their improvement in pain relief on a scale from one to 10, the majority rated it at "between 9 and 10".

Without their knowledge, a placebo was introduced during the trial, and later replaced with cannabinoid. When the extract was removed, pain levels shot up 20 to 30 per cent, and subsequently dropped off once the extract was again provided.

Dr Notcutt said subjects reported improvements ranging from 'life-changing' to allowing them to get a good night's sleep. One subject had returned to work; others had started driving, gardening and caring for children again.

In all, 17 of the 23 subjects found the extract useful in reducing pain. Of the remainder, three said it had little or no effect, two disliked the euphoria produced, and one was withdrawn from the program due to 'protocol violations'.

Previous anecdotal reports from multiple sclerosis patients have suggested that smoking cannabis has a beneficial effect. Dr Notcutt said he was interested in establishing if this was true, whether there were any side effects and what appropriate dosages might be.

Although cannabis use is illegal in most countries, some multiple sclerosis and cancer patients have been lobbying to legalise its medicinal use, particularly in Britain and the United States.

Despite his positive results, however, Dr Notcutt said more research was needed before scientists could recommend cannabis as a treatment.

"I think it's too early - we need a lot more basic information on just on how to use the drug," he told reporters. He decried the fact that, because of its status as a prohibited substance, very little is known about its pain-relieving properties.

"What we're trying to do is study it in depth, get a lot of information. What is going on, what are the effects on individual patients?"

Notcutt did the study in his own time, with cannabis extract supplied by GW Pharmaceuticals, a company licensed by the British government to grow and supply cannabis for medical research.

He said the use of cannabis extracts for pain alleviation could pave the way for the drug to be used for other conditions, including rheumatoid arthritis, epilepsy and cancer.

Studies in Europe suggest that 18 per cent of people suffer chronic pain, defined as pain that lasts six months or more.

Wilson da Silva - ABC Science Online

http://www.abc.net.au/science/news/health/HealthRepublish_358716.htm

--------------------
Heather is the Administrator of the IBS Message Boards. Sheís the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Entire thread
Subject Posted by Posted on
* Pharmaceutical HeatherAdministrator 07/14/03 01:50 PM
. * Long-term cannabis use increases risk for IBS HeatherAdministrator†† 10/19/17 04:04 PM
. * FDA approves new drug for chronic constipation HeatherAdministrator†† 01/26/17 03:05 PM
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. * FDA approves Linzess to treat certain cases of irritable bowel syndrome and constipation HeatherAdministrator†† 08/31/12 11:25 AM
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. * Antacids increase risk of pneumonia HeatherAdministrator†† 01/14/11 04:35 PM
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. * Antiobiotic Rifaximin (Xifaxan) for Patients with Irritable Bowel Syndrome without Constipation HeatherAdministrator†† 01/07/11 02:59 PM
. * Proton Pump Inhibitor Drugs Tied to 80% Increase in Clostridium difficile Risk HeatherAdministrator†† 11/10/10 11:29 AM
. * Phase 3 clinical trials of linaclotide for IBS constipation HeatherAdministrator†† 10/13/10 02:44 PM
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. * Benefit/risk ratio of Renzapride not sufficient to warrant further study in IBS-C HeatherAdministrator†† 04/07/10 01:32 PM
. * Adverse effects of drugs on small intestine and colon HeatherAdministrator†† 03/16/10 11:23 AM
. * Children's Belly Aches Don't Disappear With Antidepressant HeatherAdministrator†† 03/11/10 01:14 PM
. * Survey: Marijuana Use In Patients With IBS HeatherAdministrator†† 01/12/10 03:17 PM
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. * Clinical trial: phase 2 trial of lubiprostone for irritable bowel syndrome with constipation. HeatherAdministrator†† 02/15/08 11:20 AM
. * Role of Antibiotics vs Conventional Pharmacotherapy in Treating Symptoms of Irritable Bowel Syndrome HeatherAdministrator†† 01/03/08 04:45 PM
. * FDA permits the restricted use of Zelnorm HeatherAdministrator†† 08/09/07 11:41 AM
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. * Citalopram (Celexa) Improves Symptoms of Irritable Bowel Syndrome HeatherAdministrator†† 10/14/06 12:57 PM
. * Marijuana eases chronic pain HeatherAdministrator†† 07/17/06 11:49 AM
. * Doctors group launches war on drug ads HeatherAdministrator†† 07/17/06 11:17 AM
. * New IBS drug in development in Japan HeatherAdministrator†† 07/05/06 05:13 PM
. * Marijuana and the gastrointestinal tract HeatherAdministrator†† 06/12/06 03:38 PM
. * Zelnorm Rejected Again in Europe HeatherAdministrator†† 04/02/06 03:25 PM
. * Antidepressants for IBS HeatherAdministrator†† 03/16/06 12:31 PM
. * Takeda Laxative Wins U.S. Approval for Adults HeatherAdministrator†† 02/18/06 01:36 PM
. * Cilansetron: ; Solvay Pharmaceuticals suspends registration activites in the U.S., HeatherAdministrator†† 01/18/06 04:15 PM
. * Hearburn Drugs Cause Diarrhea HeatherAdministrator†† 01/08/06 05:10 PM
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. * Octreotide May Be Effective in Treatment of Nonconstipated IBS HeatherAdministrator†† 12/08/05 12:31 PM
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. * Efficacy and Safety of Alosetron in Men with Diarrhea-Predominant IBS HeatherAdministrator†† 02/19/05 05:56 PM
. * Irritable Bowel Syndrome Medications Side Effects Survey HeatherAdministrator†† 11/09/04 02:04 PM
. * On the Relationship Between Colon Ischemia, Irritable Bowel Syndrome, and Serotonergic Therapy of Irritable Bowel Syndrome HeatherAdministrator†† 10/24/04 07:10 PM
. * New Risk Information on Zelnorm for IBS for Women HeatherAdministrator†† 07/11/04 02:18 PM
. * The Relationship among Previous Antimicrobial Use and H. Pylori Infections HeatherAdministrator†† 06/27/04 01:33 PM
. * Therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome HeatherAdministrator†† 06/04/04 03:54 PM
. * Pharmaceutical companies funding a number of studies into IBS in the UK HeatherAdministrator†† 05/25/04 12:00 PM
. * Irritable bowel syndrome helped by Paroxetine, a drug for depression HeatherAdministrator†† 05/10/04 02:15 PM
. * Fears cause low sales of Lotronex HeatherAdministrator†† 05/10/04 01:46 PM
. * Zelnorm Warning Issued by FDA HeatherAdministrator†† 05/10/04 01:01 PM
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. * Clinical Trial Guidelines for Pharmacological Treatment of IBS - Pharmacological Options HeatherAdministrator†† 12/01/03 05:55 PM
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. * Measuring Treatment Effects in IBS Trials HeatherAdministrator†† 10/20/03 03:30 PM
. * FDA Orders Novartis To Pull Zelnorm Ads HeatherAdministrator†† 10/07/03 11:25 PM
. * Step-down dosage of PPI drugs for hearburn HeatherAdministrator†† 09/30/03 01:26 PM
. * Evaluation of drug treatment in irritable bowel syndrome HeatherAdministrator†† 09/30/03 12:52 PM
. * Pain Relievers and Intestinal Disorders HeatherAdministrator†† 09/16/03 04:20 PM
. * Hypersensitivity and hyperreactivity in IBS: opportunity for drug discovery HeatherAdministrator†† 07/18/03 12:39 PM
. * Antidepressants in the Treatment of IBS and Other Functional GI Disorders HeatherAdministrator†† 07/18/03 12:20 PM
. * Use of Antidepressants in the Treatment of IBS? HeatherAdministrator†† 07/14/03 03:58 PM
. * Combined use of SSRIs and NSAIDs increases the risk of GI adverse effects HeatherAdministrator†† 07/14/03 03:15 PM

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