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Heather

Reged: 12/09/02

Posts: 7077

Loc: Seattle, WA

Cannabinoids Show Promise for Inflammatory Bowel Disease
09/01/05 11:23 AM

Cannabinoids Show Promise for Inflammatory Bowel Disease

NEW YORK (Reuters Health) Aug 12 - Cannabis-based drugs may have therapeutic potential in inflammatory bowel disease, UK researchers report in the August issue of Gastroenterology.

"The system that responds to cannabis in the brain is present and functioning in the lining of the gut," lead researcher Dr. Karen Wright, of the University of Bath, explained to Reuters Health. "There is an increased presence of one component of this system during inflammatory bowel diseases -- Crohn's and ulcerative colitis."

Dr. Wright and her colleagues established the location of cannabinoid receptors CB1 and CB2 in human colonic tissue and used human colonic epithelial cells lines in cannabinoid-binding and in wound-healing experiments.

Expression of both receptors was detected on plasma cells in the lamina propria, but only CB2 was present on macrophages.

CB2 was increased and immunoreactivity was seen in the epithelium of colonic tissue characteristic of inflammatory bowel disease. Cannabinoids enhanced epithelial wound closure via CB1-related mechanisms.

Thus continued Dr. Wright, "cannabinoids, which we make ourselves, as well as synthetic cannabinoids, can promote wound healing in the gut, which is extremely interesting given that inflammatory bowel disease involves damaged gut linings."

Although no data are available yet, she added, relevant case studies of the use of cannabinoids are taking place in the UK and a clinical trial is being conducted in Germany.

Gastroenterology 2005.

http://www.medscape.com/viewarticle/510626?src=mp

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Heather is the Administrator of the IBS Message Boards. She’s the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Subject	Posted by	Posted on
Inflammatory Bowel Disease	Heather	07/14/03 01:51 PM
Genetic Clues May Help Unravel Cause of Crohn's	Heather	11/02/12 12:59 PM
Inflammatory bowel, ulcerative colitis linked to intestinal fungi	Heather	06/15/12 01:23 PM
Smoking makes Crohn's disease worse	Heather	05/09/12 01:33 PM
Kids With Crohn’s Disease, Colitis Often Struggle at School	Heather	04/23/12 01:22 PM
As Nations Develop, So May Bowel Disease	Heather	01/09/12 12:01 PM
Loneliness Triggers Inflammatory Illnesses	Heather	02/10/11 10:05 AM
Infants' antibiotic use tied to IBD risk	Heather	11/03/10 01:42 PM
Olive Oil May Protect Against Ulcerative Colitis	Heather	05/05/10 10:32 AM
Accutane may cause ulcerative colitis	Heather	04/09/10 01:38 PM
Red meat may raise odds for ulcerative colitis, but oily fish could be protective	Heather	03/11/10 01:22 PM
Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified?	Heather	01/05/10 12:03 PM
Novel Compound Targets Mucosal Healing in Crohn's	Heather	05/29/06 02:19 PM
Viagra May Help Crohn's Disease	Heather	03/04/06 12:50 PM
Carbon Monoxide Eases Ulcerative Colitis	Heather	01/18/06 04:12 PM
Colonoscopic Surveillance in Inflammatory Bowel Disease	Heather	10/11/05 01:33 PM
Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease	Heather	09/13/05 01:22 PM
Cannabinoids Show Promise for Inflammatory Bowel Disease	Heather	09/01/05 11:23 AM
Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome	Heather	09/01/05 11:13 AM
The Clinical Epidemiology of Inflammatory Bowel Disease	Heather	08/22/05 04:45 PM
IBD Patients May Benefit From Folic Acid Supplementation	Heather	05/22/05 07:02 PM
Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis	Heather	04/24/05 03:33 PM
Biotic Therapy Cuts Inflammation in Ulcerative Colitis	Heather	02/19/05 05:59 PM
Calming Crohn's Disease with Fish Oil and Antioxidants	Heather	01/07/05 04:55 PM
Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis	Heather	12/20/04 01:37 PM
Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden?	Heather	11/28/04 02:58 PM
Diet May Influence Relapse in Ulcerative Colitis	Heather	10/24/04 07:50 PM
Parasite Therapy for Crohn's and Colitis?	Heather	08/08/04 03:00 PM
Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases	Heather	06/04/04 06:41 PM
Faulty Gene for Crohn's Disease Found	Heather	04/13/04 03:19 PM
Data links Crohn's disease and antibiotics	Heather	02/24/04 02:07 PM
Elan Reports Successful Results of Antegren Trial for Crohn's Disease	Heather	02/10/04 01:30 PM
5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer	Heather	02/10/04 01:29 PM
Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis	Heather	01/26/04 03:33 PM
Bone Disease and Intestinal Problems May Share a Common Cause	Heather	01/07/04 11:47 AM
Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease	Heather	12/16/03 11:59 AM
Environmental Factors May Play a Role in the Pathogenesis of IBD	Heather	12/01/03 05:56 PM
Colonoscopy Prep	Heather	10/17/03 12:05 PM
Detection of Pulmonary Involvement in Inflammatory Bowel Disease	Heather	09/30/03 01:20 PM
Indeterminate Colitis	Heather	09/16/03 03:33 PM
Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease	Heather	09/16/03 03:30 PM
Bacteria in Milk Linked to Crohn's Disease and Possibly IBS	Heather	08/12/03 11:55 AM
Inflammatory Bowel Disease During Pregnancy.	Heather	07/15/03 06:20 PM
A study of the menopause, smoking, and contraception in women with Crohn's disease.	Heather	07/15/03 06:05 PM
Hormone replacement therapy prevents bone loss in patients with IBD	Heather	07/15/03 06:02 PM
Chemo Drug Improves Crohn's Symptoms	Heather	07/14/03 04:09 PM

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