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HeatherAdministrator

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Bowel habit in irritable bowel syndrome in women: Defining an alternator
      04/10/05 06:18 PM

Gastroenterology, March 2005 • Volume 128 • Number 3

Clinical-alimentary Tract

A prospective assessment of bowel habit in irritable bowel syndrome in women: Defining an alternator

Douglas A. Drossman *
Carolyn B. Morris *
Yuming Hu *
Brenda B. Toner ‡ Nicholas Diamant ‡
Jane Leserman * ]
Michael Shetzline §
Christine Dalton *
Shrikant I. Bangdiwala *


Background & Aims: Irritable bowel syndrome (IBS) is subtyped as IBS with diarrhea (IBS-D) or IBS with constipation (IBS-C) based on Rome II guidelines. The remaining group is considered as having mixed IBS (IBS-M). There is no standard definition of an alternator (IBS-A), in which bowel habit changes over time. Our aim was to use Rome II criteria to prospectively assess change in bowel habit for more than 1 year to understand IBS-A. Methods: Female patients (n = 317) with IBS entering a National Institutes of Health treatment trial were studied at baseline with questionnaires and 2-week daily diary cards of pain and stool frequency and consistency. Studies were repeated at the end of treatment (3 months) and at four 3-month intervals for one more year. Algorithms to classify subjects into IBS-D, IBS-C, and IBS-M groups used diary card information and modified Rome II definitions. Changes in bowel habit at 3-month intervals were then assessed using these surrogate diary card measures. Results: At baseline, 36% had IBS-D, 31% IBS-M, and 34% IBS-C. Except for stool frequency, there were no differences between groups. While the proportion of subjects in each subgroup remained the same over the year, most individuals (more than 75%) changed to either of the other 2 subtypes at least once. IBS-M was the least stable (50% changed out by 12 weeks). Patients were more likely to transition between IBS-M and IBS-C than between IBS-D and IBS-M. Notably, only 29% switched between the IBS-D and IBS-C subtypes over the year. Conclusions: While the proportion of subjects in each of the IBS subtypes stays the same, individuals commonly transition between subtypes, particularly between IBS-M and IBS-C. We recommend that IBS-A be defined as at least one change between IBS-D and IBS-C by Rome II criteria over a 1-year period.

http://www2.gastrojournal.org/scripts/om.dll/serve?action=searchDB&searchDBfor=art&artType=abs&id=as0016508504021973&nav=abs

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Subject Posted by Posted on
* Gender / Hormones HeatherAdministrator 07/14/03 01:57 PM
. * Pain management in women is often overlooked and ineffective HeatherAdministrator   02/16/15 04:42 PM
. * Women, Hormones and IBS HeatherAdministrator   03/11/14 02:09 PM
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. * Constipation and Risk of Cardiovascular Disease among Postmenopausal Women HeatherAdministrator   08/03/11 03:58 PM
. * Differences in Gastrointestinal Symptoms According to Gender in Rome II Positive IBS and Dyspepsia HeatherAdministrator   03/11/10 01:51 PM
. * Gender-related differences in prepulse inhibition of startle in irritable bowel syndrome HeatherAdministrator   03/11/10 01:48 PM
. * No evidence of sex differences in heritability of irritable bowel syndrome HeatherAdministrator   03/31/08 11:36 AM
. * Acupuncture for the treatment of pain from a gender perspective. HeatherAdministrator   03/31/08 11:27 AM
. * The menstrual cycle and its effect on inflammatory bowel disease and irritable bowel syndrome HeatherAdministrator   11/07/07 02:35 PM
. * Irritable Bowel Syndrome Is More Common in Women Regardless of the Menstrual Phase HeatherAdministrator   11/07/07 02:31 PM
. * Pelvic floor dysfunction and IBS in patients with interstitial cystitis. HeatherAdministrator   10/10/07 12:33 PM
. * Women with IBS have abnormal pain modulation HeatherAdministrator   10/10/07 12:01 PM
. * Anxiety or Depression with IBS Affects More Women Than Men HeatherAdministrator   09/24/07 11:31 AM
. * Colonoscopies more difficult and painful for women and people with IBS HeatherAdministrator   09/24/07 11:22 AM
. * Role of gender and early childhood in constipation HeatherAdministrator   09/13/07 11:09 AM
. * Changes in Bowel Function: Pregnancy and the Puerperium HeatherAdministrator   03/01/07 01:39 PM
. * Drugs for gastrointestinal disorders in pregnant women. HeatherAdministrator   05/13/06 03:20 PM
. * Functional bowel disorders in patients with pelvic organ prolapse and incontinence HeatherAdministrator   12/08/05 12:10 PM
. * Sex specific alterations in autonomic function among patients with irritable bowel syndrome HeatherAdministrator   11/12/05 01:16 PM
. * Women With Interstitial Cystitis at Risk for Irritable Bowel Syndrome and Depression HeatherAdministrator   09/22/05 04:39 PM
. * Women and Men Perceive Pain Differently HeatherAdministrator   09/13/05 12:55 PM
. * Overlapping Conditions in Women With Irritable Bowel Syndrome HeatherAdministrator   04/24/05 03:58 PM
. * Bowel habit in irritable bowel syndrome in women: Defining an alternator HeatherAdministrator   04/10/05 06:18 PM
. * Recognition and treatment of irritable bowel syndrome among women with chronic pelvic pain HeatherAdministrator   03/28/05 12:18 PM
. * Irritable bowel syndrome, chronic pelvic inflammatory disease and endometriosis HeatherAdministrator   02/19/05 05:43 PM
. * A gene for diarrhoea-predominant IBS in women? HeatherAdministrator   11/28/04 02:21 PM
. * Autonomic Cardiovascular Responses Are Impaired in Women With Irritable Bowel Syndrome HeatherAdministrator   09/12/04 03:41 PM
. * Abdominal Bloating: Relation to Rectal Hypersensitivity and Menstrual Cycle HeatherAdministrator   06/27/04 01:55 PM
. * Catching Colon Cancer in Women Can Be Tough HeatherAdministrator   04/13/04 03:32 PM
. * Women More Sensitive to Pain Than Men HeatherAdministrator   04/13/04 03:31 PM
. * Gender Differences In Brain Response To IBS Pain HeatherAdministrator   11/18/03 03:32 PM
. * After Menopause, IBS Lessens in Women HeatherAdministrator   11/04/03 03:34 PM
. * Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome? HeatherAdministrator   07/25/03 11:43 AM
. * Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome. HeatherAdministrator   07/18/03 01:00 PM
. * Symptoms across the menstrual cycle in women with irritable bowel syndrome. HeatherAdministrator   07/18/03 12:58 PM
. * Does a physically active lifestyle improve symptoms in women with irritable bowel syndrome? HeatherAdministrator   07/18/03 12:54 PM
. * Relation between hysterectomy and the irritable bowel HeatherAdministrator   07/18/03 11:48 AM
. * Diagnosis and management of IBS, constipation, and diarrhea in pregnancy. HeatherAdministrator   07/18/03 11:47 AM
. * Physician perception of IBS management in women and men. HeatherAdministrator   07/15/03 06:38 PM
. * Gender issues in the management of IBD and IBS HeatherAdministrator   07/15/03 06:11 PM
. * Gender differences in gut transit HeatherAdministrator   07/15/03 06:07 PM
. * Bowel dysfunction in postmenopausal women. HeatherAdministrator   07/15/03 06:04 PM
. * Irritable Bowel Syndrome Worse During Periods HeatherAdministrator   07/14/03 03:25 PM
. * Sex-related differences in IBS patients: Central processing of visceral stimuli HeatherAdministrator   07/14/03 02:40 PM

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