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All Boards >> Irritable Bowel Syndrome Research Library

HeatherAdministrator

Reged: 12/09/02
Posts: 7471
Loc: Seattle, WA
Chemo Drug Improves Crohn's Symptoms
07/14/03 04:09 PM

Chemo Drug Improves Crohn's Symptoms - Immune-Boosting Therapy Opposite of Standard Treatment

By Sid Kirchheimer
WebMD Medical News

Nov. 7, 2002 -- The painful and debilitating symptoms of Crohn's disease may be eased or even eliminated by a seemingly unlikely source -- a drug primarily used to boost immunity. A study shows Leukine to be a unique and promising new approach to treat the disease.


The irony: Crohn's has been thought to result from an overactive immune system, and traditional therapies have attempted to suppress -- not enhance -- immune activity.


Yet researchers discovered that the drug Leukine, which strengthens immune response by increasing the size and function of white blood cells, offered "significant improvement" in symptom relief for 12 of 15 Crohn's patients -- that's 80% -- who were part of the first study using this therapy.


Of those, eight went into remission, says researcher Joshua Korzenik, MD, of Washington University School of Medicine and a Crohn's specialist at Barnes-Jewish Hospital in St. Louis.


"It's a small study, but the outcome exceeded our expectations, especially since people were saying that the idea of stimulating immune systems that are already revved up is like throwing oil onto a raging fire," he tells WebMD. "While this treatment approach certainly isn't prime-time yet, we're extremely excited because it offers a different approach and new understanding to a disease that has defied explanation."


His findings, published in the Nov. 9 issue of The Lancet, are now the subject of a follow-up study at 30 sites throughout the U.S. If future findings are similarly promising, Leukine might be available for Crohn's patients within five years, says Korzenik. It is usually used in cancer patients who are undergoing chemotherapy.


Leukine could provide some relief to a baffling condition that plagues nearly 500,000 Americans, causing extreme pain, diarrhea, ulcers, and other inflammation in the intestines.


"What's particularly heinous about Crohn's is the typical onset occurs in the teens or early 20s, a time when people are establishing their self-identity," notes researcher Brian Dieckgraefe, MD, PhD, also at Washington University. "So, as if going through your teens isn't bad enough, these patients also have severe daily abdominal pain, diarrhea, intestinal ulcers and abscesses."


Therapy for Crohn's patients currently involves several immune-suppressing drugs, including steroids. But many cause side effects not experienced by the test subjects using Leukine, says Korzenik. Only one medication is specifically approved by the FDA to treat Crohn's -- Remicade, which is also used to treat rheumatoid arthritis.


"But Remicade requires continuous infusion, whereas Leukine is injected, so it's a lot easier to administer," notes Seymour Katz, MD, of New York University School of Medicine and a spokesman for the American College of Gastroenterology. "Does this mean that Leukine is the only answer for Crohn's? No. Does it offer some hope for Crohn's patients? Yes. Is this an exciting finding that brings a new approach to treatment? Absolutely."

2002 WebMD Inc. All rights reserved.

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Heather is the Administrator of the IBS Message Boards. Shes the author of Eating for IBS and The First Year: IBS, and the CEO of Heather's Tummy Care. Join her IBS Newsletter. Meet Heather on Facebook!

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Subject Posted by Posted on
* Inflammatory Bowel Disease HeatherAdministrator 07/14/03 01:51 PM
. * 7 recent developments in Crohn's disease HeatherAdministrator 04/02/15 03:16 PM
. * Hormonal contraception improved menstrual-related IBD symptoms HeatherAdministrator 09/15/14 12:43 PM
. * Fecal lactoferrin differentiated IBD from IBS HeatherAdministrator 07/29/14 01:50 PM
. * Vitamin D and Cancer Risk in IBD HeatherAdministrator 07/15/14 02:53 PM
. * Self-assessment scale developed for patients with IBD-fatigue HeatherAdministrator 06/17/14 10:44 AM
. * Stool test distinguishes between IBD and IBS HeatherAdministrator 04/07/14 01:40 PM
. * Breathing exercises, meditation improved inflammatory markers, quality of life in IBD patients HeatherAdministrator 10/23/13 04:20 PM
. * Inflammatory Bowel Disease: Heat Waves Linked to Flares HeatherAdministrator 08/16/13 12:58 PM
. * Dietary changes may reduce effects of IBD HeatherAdministrator 06/27/13 05:43 PM
. * Genetic Clues May Help Unravel Cause of Crohn's HeatherAdministrator 11/02/12 12:59 PM
. * Inflammatory bowel, ulcerative colitis linked to intestinal fungi HeatherAdministrator 06/15/12 01:23 PM
. * Smoking makes Crohn's disease worse HeatherAdministrator 05/09/12 01:33 PM
. * Kids With Crohns Disease, Colitis Often Struggle at School HeatherAdministrator 04/23/12 01:22 PM
. * As Nations Develop, So May Bowel Disease HeatherAdministrator 01/09/12 12:01 PM
. * Loneliness Triggers Inflammatory Illnesses HeatherAdministrator 02/10/11 10:05 AM
. * Infants' antibiotic use tied to IBD risk HeatherAdministrator 11/03/10 01:42 PM
. * Olive Oil May Protect Against Ulcerative Colitis HeatherAdministrator 05/05/10 10:32 AM
. * Accutane may cause ulcerative colitis HeatherAdministrator 04/09/10 01:38 PM
. * Red meat may raise odds for ulcerative colitis, but oily fish could be protective HeatherAdministrator 03/11/10 01:22 PM
. * Inflammatory Bowel Disease and Irritable Bowel Syndrome: Separate or Unified? HeatherAdministrator 01/05/10 12:03 PM
. * Novel Compound Targets Mucosal Healing in Crohn's HeatherAdministrator 05/29/06 02:19 PM
. * Viagra May Help Crohn's Disease HeatherAdministrator 03/04/06 12:50 PM
. * Carbon Monoxide Eases Ulcerative Colitis HeatherAdministrator 01/18/06 04:12 PM
. * Colonoscopic Surveillance in Inflammatory Bowel Disease HeatherAdministrator 10/11/05 01:33 PM
. * Oral Contraceptives and HRT a Risk Factor for Inflammatory Bowel Disease HeatherAdministrator 09/13/05 01:22 PM
. * Cannabinoids Show Promise for Inflammatory Bowel Disease HeatherAdministrator 09/01/05 11:23 AM
. * Differentiation of Inflammatory Bowel Disease and Irritable Bowel Syndrome HeatherAdministrator 09/01/05 11:13 AM
. * The Clinical Epidemiology of Inflammatory Bowel Disease HeatherAdministrator 08/22/05 04:45 PM
. * IBD Patients May Benefit From Folic Acid Supplementation HeatherAdministrator 05/22/05 07:02 PM
. * Fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis HeatherAdministrator 04/24/05 03:33 PM
. * Biotic Therapy Cuts Inflammation in Ulcerative Colitis HeatherAdministrator 02/19/05 05:59 PM
. * Calming Crohn's Disease with Fish Oil and Antioxidants HeatherAdministrator 01/07/05 04:55 PM
. * Probiotics Prove Just As Effective As a Popular Prescription Drug for Ulcerative Colitis HeatherAdministrator 12/20/04 01:37 PM
. * Increased Incidence of Inflammatory Bowel Disease: The Price of the Decline of Infectious Burden? HeatherAdministrator 11/28/04 02:58 PM
. * Diet May Influence Relapse in Ulcerative Colitis HeatherAdministrator 10/24/04 07:50 PM
. * Parasite Therapy for Crohn's and Colitis? HeatherAdministrator 08/08/04 03:00 PM
. * Pipeline Treatments, Novel Procedures Offer New Options for GI Diseases HeatherAdministrator 06/04/04 06:41 PM
. * Faulty Gene for Crohn's Disease Found HeatherAdministrator 04/13/04 03:19 PM
. * Data links Crohn's disease and antibiotics HeatherAdministrator 02/24/04 02:07 PM
. * Elan Reports Successful Results of Antegren Trial for Crohn's Disease HeatherAdministrator 02/10/04 01:30 PM
. * 5-ASA Therapy for Inflammatory Bowel Disease No Bar to Colon Cancer HeatherAdministrator 02/10/04 01:29 PM
. * Once-Daily Probiotic Treatment Maintains Remission in Ulcerative Colitis patients with Pouchitis HeatherAdministrator 01/26/04 03:33 PM
. * Bone Disease and Intestinal Problems May Share a Common Cause HeatherAdministrator 01/07/04 11:47 AM
. * Increased Anal Resting Pressure and Rectal Sensitivity in Crohn's Disease HeatherAdministrator 12/16/03 11:59 AM
. * Environmental Factors May Play a Role in the Pathogenesis of IBD HeatherAdministrator 12/01/03 05:56 PM
. * Colonoscopy Prep HeatherAdministrator 10/17/03 12:05 PM
. * Detection of Pulmonary Involvement in Inflammatory Bowel Disease HeatherAdministrator 09/30/03 01:20 PM
. * Indeterminate Colitis HeatherAdministrator 09/16/03 03:33 PM
. * Familial Occurrence of Inflammatory Bowel Disease in Celiac Disease HeatherAdministrator 09/16/03 03:30 PM
. * Bacteria in Milk Linked to Crohn's Disease and Possibly IBS HeatherAdministrator 08/12/03 11:55 AM
. * Inflammatory Bowel Disease During Pregnancy. HeatherAdministrator 07/15/03 06:20 PM
. * A study of the menopause, smoking, and contraception in women with Crohn's disease. HeatherAdministrator 07/15/03 06:05 PM
. * Hormone replacement therapy prevents bone loss in patients with IBD HeatherAdministrator 07/15/03 06:02 PM
. * Chemo Drug Improves Crohn's Symptoms HeatherAdministrator 07/14/03 04:09 PM

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