I am currently taking Paxil. I have IBS-C. In terms of improvement, it has taken a lot of the anxiety away that I have. I think Paxil really works to change the way you are thinking and thus letting you deal with IBS and its attacks. Without worrying all the time, I'm not as stressed and anxious about having another attack. The side effects and the cons - it is a powerful drug that takes time to get off of once you start; my sexual drive has definately decreased, which has been a bad side effect for me; some people say that there may be a sleeplessness, but I actually sleep better since I am not worrying. Overall, it has been a wonderful drug for me. When I get down about IBS, it doesn't allow my mood to drop as much as it used it. It is easier for me to deal with an attack when it happens. I hope that this answers your questions.