prostaglandin and IBS
#299336 - 02/08/07 11:22 AM
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tomoko
Reged: 04/20/04
Posts: 39
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This has been talked about Heather and the others in the past. Some people experience worsening of IBS symptoms before the period because of the increased level of the prostaglandin (I think it's called E2).
Is there any way to lower the level of prostaglandin?
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NSAIDs (Celebrix, Ibuprofen, Aspirin, etc ) are known to reduce prostaglandin synthesis.
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Wouldn't these be bad for IBS?
Any natural or/and food sources?
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I cannot tolerate any NSAIDs. They can be very hard on the GI system. For example, aspirin can promote stomach ulcers. I used Tylenol . Its effect on prostaglandin is different from the NSAIDs. It acts indirectly on it and therefore it is not an anti-inflammatory.
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STABLE: ♂, IBS-D 50+ years - Science of IBS
The FODMAP Approach to Managing IBS Symptoms
Evidence-based Dietary Management of Functional GI Symptoms: The FODMAP Approach
FODMAP Chart & Cheatsheet
The Role of Food & Dietary Intervention in IBS
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My OB/GYN told me that prostaglandin causes D and headaches on it's own, so of course, if you already have D, well... you know how it goes.
I was able to get this under control with birth control.
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Yeah, that is probably why Tylenol doesn't work on my IBS pain before my period. Tylenol barely works for my menstruation pain either, at least for me.
What kind of birth control are you taking? (I probably won't go that route, but in my desperation, I would consider it.)
So anybody know of any prostaglandin reducing food or supplements??
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I take birth control pills (orthocyclen) to help reduce my cramps. NSAIDs did help with the cramps - I'd start taking them 1 - 2 days before my period - but they were terrible for my upper GI tract. Tylenol didn't help at all. Disposable heat wraps that you can wear all day really help a lot too, as well as peppermint tea.
As far as consuming food or supplements to help, I'm not sure. I heard once that taking a calcium supplement can help reduce cramps and/or PMS symptoms, but I haven't found any studies on this and I'm not sure if it works by reducing prostaglandins or what. NSAIDs are the only things that I know for sure reduce prostaglandins.
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I'm actually not on BC now, hubby and I have decided to start trying for a baby.
But in the past I've tried:
Ortho Tricyclen
Seasonale
Ortho Evra
Levora - this was most current.
They all helped with PMS and attacks triggered around that time of the month. There now is some controversy surrounding Ortho Evra (the patch) and it's not so popular now. Levora was what I took most recently and it worked very well to help keep symptoms under control (both menstrual and IBS) and I had no side effects when I started taking it.
I use Aleve for menstrual cramps. It works well for me w/o bothering my stomach.
I don't know what kind of, if any, foods will help with prostaglandin. Sorry. 
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OK, someone with bio science or bio chemistry background...
What does this say?
http://www.blackwell-synergy.com/links/doi/10.1046/j.1432-1327.1999.00630.x
Does this say Resveratrol reduces prostaglandin (E2)?
Thanks!
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This article says that resveratrol (found in red wine) prevents cell death in a specific kind of cancer cell - human erythroleukemia K562 cells. These cells were grown in a liquid media culture in the laboratory (i.e. the cells did not reside in the human body). The resveratrol and other agents that were being tested were dissolved in methanol and then added to the growth media. Resveratrol reduced the elevation of prostaglandin E2 induced by hydrogen peroxide in these cells. Hydrogen peroxide plays a role in programmed cell death (apoptosis). Resveratrol was shown to inhibit the cyclooxygenase activity of the prostaglandin H synthase enzyme. This enzyme is involved the biosynthesis of the prostaglandins.
In summary, the article shows that resveratrol reduces prostaglandins in a very specific cell under very specific conditions. The authors of the article conclude the findings "may give a biochemical background to the effect of this compound [resveratrol] in coronary heart disease and cancer prevention." The results cannot be generalized to say that drinking red wine will decrease prostaglandin E2 production.
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STABLE: ♂, IBS-D 50+ years - Science of IBS
The FODMAP Approach to Managing IBS Symptoms
Evidence-based Dietary Management of Functional GI Symptoms: The FODMAP Approach
FODMAP Chart & Cheatsheet
The Role of Food & Dietary Intervention in IBS
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