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The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome.

Dig Dis Sci. 2010 May;55(5):1385-90. doi: 10.1007/s10620-009-0854-9. Epub 2009 Jun 9.

The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome.

Merat S, Khalili S, Mostajabi P, Ghorbani A, Ansari R, Malekzadeh R.
Source

Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Sciences, N Kargar St, 14117 Tehran, Iran.
Abstract

Herbal remedies, particularly peppermint, have been reported to be helpful in controlling symptoms of irritable bowel syndrome (IBS). We conducted a randomized double-blind placebo-controlled study on 90 outpatients with IBS. Subjects took one capsule of enteric-coated, delayed-release peppermint oil or placebo three times daily for 8 weeks. We visited patients after the first, fourth, and eighth weeks and evaluated their symptoms and quality of life. The number of subjects free from abdominal pain or discomfort changed from 0 at week 0 to 14 at week 8 in the peppermint group and from 0 to 6 in controls (P < 0.001). The severity of abdominal pain was also reduced significantly in the peppermint group as compared to controls. Furthermore, peppermint significantly improved the quality of life. There was no significant adverse reaction. Peppermint oil capsules are effective and safe as a therapeutic agent in patients with IBS suffering from abdominal pain or discomfort.

PMID:
19507027
[PubMed - indexed for MEDLINE]

http://www.ncbi.nlm.nih.gov/pubmed/19507027



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