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09/22/05 04:26 PM
A probiotic mixture alleviates symptoms in irritable bowel syndrome patients

Alimentary Pharmacology & Therapeutics
Volume 22 Issue 5 Page 387 - September 2005
doi:10.1111/j.1365-2036.2005.02579.x


A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention

K. KAJANDER*,, K. HATAKKA*, T. POUSSA, M. FÄRKKILħ & R. KORPELA*,,¶

Summary

Background: Irritable bowel syndrome is a gastrointestinal disorder of unknown aetiology. The effect of probiotics in this syndrome remains unclear.

Aim: To investigate whether a probiotic mixture containing Lactobacillus rhamnosus GG, L. rhamnosus LC705, Bifidobacterium breve Bb99 and Propionibacterium freudenreichii ssp. shermanii JS is effective in alleviating irritable bowel syndrome symptoms.

Methods: A total of 103 patients fulfilling the Rome I or II criteria took part in this 6-month, randomized, double-blind placebo-controlled trial. The patients received a probiotic capsule or a placebo capsule daily. Gastrointestinal symptoms and bowel habits were recorded.

Results: At the end the total symptom score (abdominal pain + distension + flatulence + borborygmi) was 7.7 (95% CI: 13.9 to 1.6) points lower in the probiotic group (P = 0.015). This represents a median reduction of 42% in the symptom score of the probiotic group compared with 6% in the placebo group. In individual symptoms, borborygmi was milder in the probiotic group (P = 0.008), and for the rest of the symptoms there was a non-significant trend.

Conclusions: The results indicate that this probiotic mixture is effective in alleviating irritable bowel syndrome symptoms. Considering the high prevalence of irritable bowel syndrome and the lack of effective therapies, even a slight reduction in symptoms could have positive public health consequences.

http://www.mdlinx.com/GILinx/thearts.cfm?artid=1326908&specid=13&ok=yes



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